Our discovery of mutations in the CIDEB gene that protect against liver disease is published in NEJM, leading to possible #RNAi therapeutics for NASH by Regeneron & Alnylam. 🚨 nejm.org/doi/full/10.10… A short summary of the key findings 🧬🧵↓

Importantly CIDEB mutations show the largest protection of liver disease in obese people, also lower liver inflammation in bariatric surgery patients from Geisinger Research: A very important finding because #obesity is THE #1 risk factor for #NASH.

The amazing thing of Regeneron Genetics Center is that we now “pass the baton” to our colleagues and top-notch medicine developers to drive the CIDEB program forward. And now back at it: unearthing protective human genetics that may lead to new medicines.Stay tuned! bit.ly/3biYQhQ

🚨 Publication alert: largest to date multiancestry exome analysis of body fat distribution discovers INHBE mutations associated with favorable adiposity and PROTECTION from diabetes! 🚨 Out today in Nature Communications 👇🧵 key takeaways below… nature.com/articles/s4146…

My personal gratitude to @J__Stock for his partnership on so much of our TOPMed #CHIP work. Josh has written TWO first author Nature papers and another forthcoming manuscript in Science Advances -- a singularly impressive PhD track record! nature.com/articles/s4158…

A 🧵 on some of my intuitions/priors about the genetics of complex and molecular traits in humans (i.e. what I think of as typical), largely motivated by GWAS/QTL studies over the past decade [citing papers with nice figures where possible]

⁦Ewan Birney⁩ I am not worthy! It’s like comparing a nice coffee that the barista just prepared in your local coffee joint with the instant coffee you found on the counter and warmed in the microwave!

An actual civil war in the world’s biggest nuclear state. I pray for the people of Russia, Ukraine and all of us. wsj.com/livecoverage/r…

Not sure how you can look at this data, ostensibly be interested in either meritocracy or equality, and want to move away from standardized tests. It's the subjective measures that are most slanted in favor of the rich kids. nytimes.com/interactive/20…

Music Artists as Superheroes This satire teaser was ENTIRELY made with AI 🤯 Images (Midjourney) + Motion (RunwayML Gen2) A THREAD 🧵👇 SOUND ON 🔊

Very touching “Stand Up 2 Cancer” moment in the Yankees - Dodgers World Series. As geneticists and scientists, we should stand up 2 cancer too. It’s incredible what targeted therapies have done, and we are only skimming the surface of what they can do. Watch this space.

Red is delayed. LaGuardia today. 1/67 flights is on time.