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If you are working in distributed computing and need to build / be motivated on the usage of distributed computing - just make sure you are aware of Folding@home Fold is a brilliant concept which caught a lot of attention during the covid19 phase. Mainly for protein folding.

Thanks to everyone Folding@home for helping generate this! For reference, a good paper in our field may have 10 microseconds of data. So 2.1 milliseconds of data is like having 210 papers worth of data. And that's just the tip of the iceberg!

Check out our rig😀 foldingathome.org/2024/08/08/the…

2/ I recently joined the AI + a16z podcast, to discuss this plus: * My work developing the Folding@home, a distributed computing project to harness global computational power for biological research a16z.com/podcast/why-co…

Exciting to see our illustrious founder continuing to do great things!

Congrats to walterthurmond on jumping 855 positions on the leader board! Thanks walterthurmond for contributing!

Data organization is up to 17 milliseconds of simulations, taking 22 TB on disk, and still just getting started😀 #compchem Folding@home

This cryptic pocket has a function! The VP35 protein from Ebola virus performs multiple functions. We wanted to know if it toggles between different conformations that are responsible for different functions. It does! biorxiv.org/content/10.110…

Its always fun to see how natural selection uses everything at its disposal, including rare protein structures that are hard to even detect. Even when this cryptic pocket is only open ~2% of the time, its still performing an important function.

Congrats to team AFGamers on jumping 691 positions on the leader board!

Woohoo, our paper on the mechanism of a G protein inhibitor that is specific to one family of G proteins is out! Nice collab with the Blumer nad ASoranno labs pnas.org/doi/10.1073/pn…

Now available open access! AlphaFold and Protein Folding: Not Dead Yet! The Frontier Is Conformational Ensembles annualreviews.org/content/journa…

Exciting new work on why the cryptic pockets that we've been hunting for exist foldingathome.org/2024/09/09/fun…

Congratulations to Susanna Susanna Barrett from Mitchell group Chemistry at Illinois and Song from Shukla Group ChBE Illinois for their work on understanding how enzymes tie the lasso knot in peptides published in Nature Chemical Biology Nature Chemical Biology! igb.illinois.edu/article/resear…

Want to do something meaningful with your computer? Contribute your computing power to Folding@home to accelerate biomedical research! foldingathome.org/start-folding/

We're making good progress on predicting properties of small molecules that are important determinants of whether they can be good drugs. Read more! foldingathome.org/2024/10/03/pre…

Wow, cool to see that team Banana has overtaken "Default (No team specified)", closely followed by LinusTechTips! BANANO Linus Tech Tips

Happy new year! 2024 was a productive year, and 2025 stands to be even more exciting! Our thanks to everyone who helped, and some reflections: foldingathome.org/2025/01/09/hap…