All researchers who engage with NIH should read these recommendations carefully and submit comments by the August 16th deadline. Some pretty big bombshells tucked in there (e.g. 3-grant cap and ideas to limit indirects)

This is a fantastic piece of journalism that rings very close to home yet it's message perhaps even extends beyond the scope intended by Packer

I'm happy to share the results of my rotation with Heng Li: biorxiv.org/content/10.110… We co-assembled reads from paired tumor-normal samples, then examined the structure of the co-assembly graph to identify large-scale somatic structural variation (focusing on translocations)

Some muses on data engineering. TL;DR much of science is happening in a computer, not least AI. This is often called "Data Science", but as well as data science, one also needs Data Engineering - assembling, manipulating, verifying and curating data to be "science ready"

This is pretty incredible - and the future of our field

Stellar discussions and even better company

Synchronous L1 retrotransposition events promote chromosomal crossover early in human tumorigenesis biorxiv.org/content/10.110…

Excited to share that our paper on a foundation AI model for cancer prognosis and pathology diagnosis is published in Nature today. nature.com/articles/s4158… DBMI at Harvard Med NIH @NIGMS CDMRP American Cancer Society #AI #DigitalPathology

pretty cool result: using a new mathematical model, scientists estimate that the ancestral human population shrunk to just 1280 individuals about 900,000 years ago. We almost went extinct, but... science.org/doi/10.1126/sc…

Excited to be launching COSMO. If you are looking to generate spatial transcriptomics data please reach out!

Prestige signals and pedigree are anathema to the scientific endeavor and quite harmful to the community of scientists actively working to advance human knowledge.

Let me introduce Transipedia, our project for cancer RNA-seq exploration just published in Genome Biology, with Chloé BESSIERE, Camille Marchet @[email protected], Rayan Chikhi, HLXue, M. Salson and Thérèse Commes’ lab in Montpellier. 1/9 👇link.springer.com/article/10.118…

In rdcu.be/dXA1e, rayan, Yoann Dufresne and I comment on the decoupling of ‘population’ pangenome graphs from ‘application-specific’ pangenome graphs. (1/3)

A comprehensive survey of RNA modifications in a human transcriptome biorxiv.org/cgi/content/sh… #biorxiv_genomic

Investigating structural variants? I just released a tutorial video showing how I do this quickly and intuitively using my tools Ribbon and SplitThreader: youtu.be/TP-H9epbsTM

I roughly calculated the state-level economic impact of withholding NIH grants in terms of jobs lost per day. For Missouri it's 79--553 jobs a week that this drags on. Data: docs.google.com/spreadsheets/d… How to contact your representatives with this information: usa.gov/elected-offici…

Two weeks ago we shared our lab's first manuscript on bioRxiv: biorxiv.org/content/10.110… We performed diploid genome assembly to fully resolve the telomeres, centromeres and numerous other repeats of the BJ and IMR-90 fibroblast cell lines. Please get in touch with feedback!