Thrilled to receive Science & SciLifeLab Prize in my category! Thanks again for the amazing support during my PhD Cai Lab Caltech. I am also super excited for the future of the spatial multi-omics field! science.org/doi/full/10.11…

Our preprint on the development of PerturbView, an Optical Pooled Screening (OPS) technology, is out! Massive thanks to Eric Lubeck for driving the project with me, along with our fantastic mentors, Orit Rozenblatt-Rosen, Levi A. Garraway and Aviv Regev biorxiv.org/content/10.110… 1/

Our first paper is out in Cell! Led by Rohith Rajasekaran, we present a programmable reaction-diffusion system that generates synthetic protein waves, oscillations, and patterns for spatiotemporal circuit design and FM data-encoding in human cells. authors.elsevier.com/a/1iN8ZL7PXmeeN

Just posted a preprint on our new spatial genomic recording system, baseMEMOIR. biorxiv.org/content/10.110… Motivation: Cells divide, differentiate, and migrate to form exquisitely organized tissues. Reconstructing the dynamic histories of individual cells, including their lineage

So excited to finally see this out in its final form!!! nature.com/articles/s4158…

Seeking someone looking for a two-year postbac position to get my group up and running at Yale University! We will be utilizing chromatin tracing and other multiplexed imaging approaches to study the relationship between 3D genome organization and epigenetic memory in embryos!

A long sought after hypothesis has been that organizing biomolecules in and around nuclear bodies is essential for functional RNA processing. We now provide direct evidence of this in nature for nuclear speckles and mRNA splicing. Check out this thread! nature.com/articles/s4158…

We are hiring a lab manager/research assistant! More details and how to apply here: bintulab.com/2024/06/01/hir…

San Francisco is a city where 70-year-old streetcars share the roads with driverless cars.

Apparently, you can subscribe to brain organoids and stimulate them through a Python API for $500/mo. What would you do with them? finalspark.com/neuroplatform/

Do human RNA-binding proteins have modular regulatory domains that downregulate RNA lifetimes? Our preprint Bintu Lab studying this question is now out on bioRxiv, where we indeed identify small domains in RBPs that potently induce RNA degradation! biorxiv.org/content/10.110… (1/9)

Delighted to see our work tiny.cc/icuazz from the Canzio lab UC San Francisco on how #cohesin-mediated enhancer-promoter interactions shape stochastic #Protocadherin choice profiles out Science Magazine. #epigenetics #chromatin #DNAmethylation #LoopExtrusion #CTCF #3Dgenome. (1/8)

🧬How do transcriptional cofactors recognize which genes to regulate?🧬 Check out our new preprint from Polly Fordyce Bintu Lab that tackles this question and provides the first-ever quantitative map of disordered transcriptional protein interactions (1/9) biorxiv.org/content/10.110…

Our paper is out! Congrats to Saori Takahashi, Hiro Kyogoku, Tomo Kitajima, and everyone involved! We discovered a 2-step transition in DNA replication regulation accompanied by transient genome instability in early mouse embryos. nature.com/articles/s4158…

I’m amped to share our new work to decrypt transcriptional repressors, now on bioRxiv: biorxiv.org/content/10.110… We paired deep mutational scans with machine learning to predict and even tune repressor activity. (1/8)

First preprint from the lab 🚨 How can enhancers regulate target promoters across vast genomic distances, and what is the role of cohesin loop extrusion in the process? biorxiv.org/content/10.110… (1)

I'm thrilled to announce that my PhD thesis work from Bintu Lab on how the H3.3K36M oncohistone disrupts the establishment of epigenetic memory is now out in the latest issue of Molecular Cell. shorturl.at/X9IZG (1/4)

Lastly, I would also like to give a shout out to Nate Hathaway’s lab UNC Pharmacy for writing a beautiful preview article elegantly describing our work. Please check it out here! : shorturl.at/hycOp (4/4)

Our new paper on epigenome editing is out! We mapped which effector domains regulate transcription across genomic, cell type and DNA-binding domain contexts. Then we built new gene repressor and activator tools with improved efficiency & deliverability nature.com/articles/s4158…

Incredibly excited that our paper linking single molecule states of TF binding to gene expression using quantitative thermodynamic models is out in Nature today. An amazing collaboration with the Bintu Lab. Congrats to Ben, Michaela, and Julia! nature.com/articles/s4158…