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"Medicine is plagued by untrustworthy clinical trials. How many studies are faked or flawed?" See how our own Alison Avenell and colleagues at University of Auckland | Waipapa Taumata Rau, Andrew Grey, Mark Bolland, and Greg Gamble our hoping to tackle this issue nature.com/articles/d4158…

A year ago I thought it might be fun to start the week with a tweet about some aspect of trial, or related, methodology - which I have tagged with #MethodologyMonday. 50+ topics later, I hope you have found some of them useful … here is a list of the topics covered so far 1/

The UK's NIHR Health Technology Assessment Programme is encouraging researchers to include SWATs evaluating alternative ways of disseminating and sharing knowledge with key evidence users. More info at: trialforge.org/2023/10/the-ni… @NIHRevidence Lindsay Bearne

No Palestinian rocket can cause the carnage & mass death we saw in that hospital. Israel warned evacuation before bombing it. Officials gloated about it before denying. Shame on all media stenographers repeating Israel’s lies to deflect the perpetrator of this egregious war crime

'People involved with the process of designing trials focus their thoughts on outcome selection, but not the practicalities of outcome collection.' ..in other words, trial teams don't think about the work collecting an outcome entails. More at doi.org/10.1186/s12874…

Last week I said that only randomised data can give truly unbiased effect estimates - this is because observational (real-world) data are affected by #SelectionBias which can skew results. A few more thoughts on this 1/8 #MethodologyMonday #62

Brimming with joy to have been awarded the Higher Performance Award from the University of Warwick Needless to say, I owe a million thank you’s to so many wonderful colleagues for their unswerving support! Prof Amy Grove yfchen Shaun Treweek Katie Gillies Joyce Keith Couper

Just published: ground-breaking study of over 23,000 RCTs in Cochrane reviews. Trials hugely underpowered for true effects. Consequently, “statistically significant” estimates seriously overestimate actual treatment effects, can’t trust them. evidence.nejm.org/doi/abs/10.105…

Placing the Methods section at the end of your article ...

Excited to have collaborated on the PRO-EDI tool with Trial Forge, Evidence Synthesis Ireland, Cochrane Ireland and The Campbell Collaboration! 🌟 This tool enhances equity, diversity, and inclusion in systematic reviews. Check out free resources & share your feedback: buff.ly/3wgPA8q

Just published Journal of Clinical Epidemiology We assessed how the overall quality of evidence (e.g. GRADE "moderate", "low" or "high" certainty) indicates if the future view on interventions changes. doi.org/10.1016/j.jcli…

Congratulations to Professor Shaun Treweek & team for receiving Bill & Melinda Gates Foundation funding aiming to improve clinical trial importance, design & integrity by new pre-funding peer review options, as studies show most clinical trials are 'bad': abdn.io/I4

This tweet was referred to in one of the #CCR24 sessions … so true. We need to move past the simplistic p<0.05 dichotomy!

I was reminded this week of the importance of taking care when interpreting subgroup analysis in clinical trials and especially the helpful role the #ICEMAN tool can play in this regard. 1/8 #MethodologyMonday #95

Chronic migraine: which drugs are best? We found out ! You can find out too at the link below evidence.nihr.ac.uk/alert/chronic-… via @NIHREvidence Warwick Evidence Warwick Med School

Love this

Another amazing trial from Clinical Trials Unit, University of Warwick. nejm.org/doi/full/10.10… #NEJM Keith Couper

Just published #JAMA Intern Med demonstrating that many #SystematicReviews of #RCTs include retracted studies and their inclusion can substantially influence results. Search for #retractions should now be standard in systematic reviews. #EBM #Medicine pubmed.ncbi.nlm.nih.gov/40163084/

When Inter needed a saviour, 37yo defender Acerbi rescued them in 93rd min. His first Euro goal. A player who was in lower leagues until 22, twice battled cancer & hit “rock bottom” after his dad died. “I started drinking & believe me I’d drink anything” Now in a UCL final ❤️