From my PhD at Romagnani Lab, we knew that viral peptides are important in guiding NK cell responses (rb.gy/clxwvp). The current project started with us exploring whether #SARSCoV2 contains peptides that could be presented on HLA-E and we indeed found some candidates

New Research: Biology and Clinical Relevance of HCMV-Associated Adaptive NK Cells: Natural killer (NK) cells are an important component of the innate immune system due to their strong ability to kill virally infected or transformed cells… frontiersin.org/articles/10.33… #immunology

#Tandem22 Plenary: CAR T and Beyond. CAR NK cell based therapies May Daher MD Anderson Cancer Center ASTCT Chimeric Antigen Receptor T-Cell (CAR-T) & Gene Rx

annualreviews.org/doi/full/10.11…

As Editor-in-Chief of Wiley Immunology (and a diehard immunologist), happy #DayofImmunology to all!

Evaluation of allogeneic and autologous membrane-bound IL-21-expanded NK cells for chronic lymphocytic leukemia therapy by Max Yano ift.tt/Mifp5ru

Z-DNA binding protein 1 promotes heatstroke-induced cell death science.org/doi/10.1126/sc…

Dr. Katharine Hsu from Memorial Sloan Kettering Cancer Center giving a spectacular Grand Rounds Fred Hutch Cancer Center this morning on NK-cell therapy. I learnt that there are T cells (NKG2C+ ) that can "impersonate" NK cells...

Very happy to see Research Briefing of our paper! I’m grateful for this opportunity. nature.com/articles/s4159…

New immune engineering of NK cells against SARS-COV-2 FROM Jianhua and colleagues: Off-the-shelf CAR natural killer cells secreting IL-15 target spike in treating COVID-19 nature.com/articles/s4146…

nature.com/articles/s4158… A tour de force of NK and T cell biology utilizing a vaccine to direct their response against the all-important NKG2D ligands 🧩

The CD8α–PILRα interaction maintains CD8+ T cell quiescence science.org/doi/10.1126/sc…

Dying cells fan the flames of inflammation science.org/doi/10.1126/sc…

Our review (with co-first authors Natalie Wolf and Djem Kissiov) of the roles of NK cells in immunity to cancer, and applications to immunotherapy of cancer, is out in Nature Reviews Immunology! nature.com/articles/s4157…

Ablation of SYK kinase from primary human Natural Killer cells via CRISPR/Cas9 enhances cytotoxicity and cytokine production biorxiv.org/content/10.110… Very interesting paper from Hart lab on NK cell biology

We are in our fourth year of work to understand #LongCovid and we now know things about it thanks to science. After being told again by a quasi-well meaning, if uninformed, clinician that LC is just functional neurological disorder (FND). Here’s a 🧵 on why LC IS NOT FND (1/)

In Science Magazine this week, Mohamed Elsharif Badr, Al Singer & al report that premature #thymic eviction is the basis for #CD8 #TCell #tolerance in mice! bit.ly/Sci_adh4124

Check out work led by Aljawharah on Natural killer cell responses during SARS-CoV-2 infection and vaccination in people living with HIV-1 nature.com/articles/s4159…

If you are interested in NK cells and cancer immunotherapy, two positions are open in Eric Vivier's lab at CIML. For more info 👇