When Isaac Asimov first published Foundation in the early 1950s, it was a revolution. Here was a vision of humanity sprawling across the stars, governed not by emperors or empires alone, but by mathematical inevitability — the grand science of psychohistory. It was the book that

1 month until ARDD 2025 - 12th Aging Research and Drug Discovery Meeting University of Copenhagen #AgingResearch Speakers include Alex Zhavoronkov, PhD (aka Aleksandrs Zavoronkovs) Max Unfried @EricVerdin Emma Teeling Andrea Maier J Scotch McClure Jamie Justice Tina Woods Marc P. Bernegger 👾 MP₿ Peter Fedichev liveforever.club/events?selecte…

Some ask why do we want to build drugs against aging. That’s why, according to others

This is true. The former CEO of Novo Nordisk actually said that addressing obesity should be done through a "radical restructuring of society" rather than with drugs like Ozempic/Wegovy. It took them a long time to realize they were wrong.

Liraglutide followed as Victoza in 2010 for diabetes, and semaglutide as Ozempic in 2017—none initially branded or approved for weight loss.That's a fair point—GLP-1 receptor agonists (GLP-1RAs) like exenatide, liraglutide, and semaglutide were indeed first pursued and approved

To wrap up our GLP-1RA saga this week, let's zoom in on one of the wildest origins stories in modern medicine. Take a look at the Gila monster (Heloderma suspectum), a chunky, slow-moving lizard from the Southwestern U.S. and Mexico deserts. Believe it or not, one of the first

Once you start adding baselines to your pipelines, life gets boring

The law that entropy always increases, —the second law of thermodynamics—holds, I think, the supreme position among the laws of Nature. If someone points out to you that your pet theory of the universe is in disagreement with Maxwell’s equations—then so much the worse for

Every mathematician knows it is impossible to understand an elementary course in thermodynamics (Arnold (1990, p. 163)

. . . no one knows what entropy really is, so in a debate you will always have the advantage (Von Neumann)