I often get photo reminders from Google, and this one took me back 9 years ago to the CRISPR CSHL conference where I presented our findings on frequent large deletions induced by single Cas9 cleavage. It was hands down the most amazing conference I've ever attended.

Excited to share that our study on generating a humanized DMD mouse model using CRISPR has been published! This model will be instrumental in advancing research for potential therapies. Huge thanks to the team for their dedication! #CRISPR #DMD #Research bmcbiol.biomedcentral.com/articles/10.11…

Wouldn't it be great if we could easily export high-quality, publication-grade figures directly from PowerPoint?

Addgene founders should get Noble prize. nature.com/articles/d4158…

Today is pluripotent day.

Just received an email from a student interested in doing an internship in our lab. Along with CRISPR gene editing, she’s into COOKING, BAKING, and COFFEE. Haven't met her yet, but I like her already.

"In 2020, Australian institutions paid over $321 million to publishers". That could have funded more than 2,500 postdoc salaries per year. F*ck the publishing system.

This is super cool.. cell.com/cell/abstract/…

Who cares 🤷. There are so many stupid metrics in academia. indaily.com.au/news/2024/10/0…

Last #apaperaday from Montreal. Traveling to Toronto today for some lectures and festivities next week. Today's pick is from BMC Biology by Chey Fatwa Adikusuma PhD et al on removing a copy of the hDMD gene of the mouse model we generated. DOI: 10.1186/s12915-024-02008-7

Our paper on continuous mutagenesis in living cells using HACE is now out in Science Magazine! We now demonstrate that HACE continuously generates mutations over a 10-day period and enables targeting using dCas9 without introducing DNA nicks. science.org/doi/10.1126/sc…

I agree with Kristofer Helgen. "All that's being promised is a genetically modified dunnart." abc.net.au/news/2024-10-1…

Researchers should be able to use their research funding to pay for Twitter or LinkedIn premium subscriptions to promote their research and papers.

The greatest challenge for #mRNA-LNP therapies is targeting non-liver tissues. To overcome this, we used customisable bispecific antibodies to tether mRNA-LNPs to cell-surface proteins, achieving efficient and selective mRNA delivery in vivo. BASE mRNA Facility biorxiv.org/content/10.110…

Nice study on large deletions induced by Cas9, BE or PE. It surprised me that there is PCR polymerase that doesn't produce amplification bias for different amplicon sizes. nature.com/articles/s4155…

I'm taking a break from Twitter and deleting the app from my phone. Bye for now.