This paper, in collaboration with Carlos Larriba-Andaluz, shows how and why ultra-high resolution IMS can separate isotopomer molecules which have the same mass and shape, and only a tiny difference in their center-of-mass (on the order of 0.01 Angstroms) pubs.acs.org/doi/10.1021/ac…

The group's first J. of the American Society for Mass Spectrometry paper is out! Please check it out to see our group's first foray into CIU. #NativeMS #CIU pubs.acs.org/doi/full/10.10…

Having carefully reviewed 2021, my recommendation is to revise and resubmit

CNRS Alsace @INEE_CNRS

Check out our last publication on the Combination of IM-Based Approaches to Unravel the Coexistence of Two Conformers on a Therapeutic Multispecific mAb 🤩 including #cyclic IMS data ⁦Sanofi en France⁩ ⁦@PhDMystery⁩ ⁦cianferani sarah⁩ pubs.acs.org/doi/10.1021/ac…

Putting the pieces together: A combination of innovative ion mobility methods including #cyclicIMS reveals the coexistence of two conformers from a trispecific therapeutic antibody LSMBOMassSpec&ProteomicsStrasbourg Sanofi en France pubs.acs.org/doi/10.1021/ac…

#PhD #phdlife #phdmemes #phdchat #phdforum #AcademicTwitter #AcademicChatter #academia #research #programming #programmer #programmingjoke #rprogramming #excel

Today I learned: Praise to your graduate students in writing, don't just tell them they're doing a good job face to face. Research on grad student depression and anxiety shows that they go back to emails or texts in particularly bad times to lift themselves up. #SABER2022

Cryo-EM samples of gas-phase purified protein assemblies using native electrospray ion-beam deposition pubs.rsc.org/en/Content/Art…

I think I've said most of what I want to say here, so I'll just post it and let others take the mic pubs.acs.org/doi/full/10.10…

🌟NEW Article🌟 A Combination of Native LC-MS Approaches for the Comprehensive Characterization of the Antibody-Drug Conjugate Trastuzumab Deruxtecan By: cianferani sarah et al. from - in #France 🔍 imrpress.com/journal/FBL/27… #Antibody_Drug_Conjugate #combine #biotech

In collisional activation ion mobility-MS, protein unfolding is thought to maintain solution-like behavior. To verify this, the Kostas Thalassinos lab used a mobile proton algorithm to study a well-known protein’s unfolding. go.acs.org/2Lu

Did it hurt? Seeing a paper of questionable methodological quality published in the journal that just rejected your manuscript?

Last piece of work from Evolène D PhD ! And a successful collaboration with Helene, Simon and David in Nantes. Thanks for the nice colorful drawings 🤩 🌈

the @hecklab survived our annual travel misadventures and arrived at #ASMS2023 ! this time? -plane hit by a bird in Amsterdam -flight canceled 10 minutes before our scheduled departure -sprint to new gate with last-minute rebook via O'Hare -entire flight loses their luggage

New technologies including charge-detection mass spectrometry, mass photometry, and nanoelectromechanical systems are allowing researchers to measure the mass of individual molecules, complexes, and particles. Read on to learn how these technologies work: fal.cn/3yPIR

#ASMS2023 Congratulations Evolène D to your excellent presentation! 25 s transients on an Orbitrap UHMR yielding 1 million resolution at m/z 12’000 - that is a great milestone!

Interested by all the Orbitrap CDMS work from us @hecklab at #ASMS2023 and how we do it? Then check out our latest paper! We discuss... (1/N) pubs.acs.org/doi/10.1021/ac…

Implementation of ultra-long transients by the @hecklab on an Orbitrap mass spectrometer improves mass resolution, sensitivity, and accuracy of charge determination in the analysis of large macromolecular ions. nature.com/articles/s4159…

Één ion 25 seconde lang opnemen, terwijl dat voorheen maar één seconde mogelijk was. Door deze ontdekking kunnen ionen nog nauwkeuriger bestudeerd worden. In dit interview vertelt Evolène Deslignière meer over deze doorbraak en haar rol hierin: nwo.nl/cases/precisie….