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🏅 CTCF- and BORIS- mediated Autophagy regulation via Alternative splicing of BNIP3L in Breast Cancer CTCF Like BORIS CTA appears to inhibit hypoxia-induced autophagy, in accord with Fig. 6 inserted below, etcetera. J Biol Chem (May 2024, in press) sciencedirect.com/science/articl…

🌟 Congratulations to Anchala ERPLab@IISERB on groundbreaking research revealing how CTCF and BORIS regulate autophagy in breast cancer via alternative splicing of BNIP3L. Special thanks to MoE-STARS for their funding support. Anchala Pandey

A recent article from Dr. Shukla’s lab on “Hypoxia-induced CTCF promotes EMT in breast cancer” is published in the Cell Reports. doi.org/10.1016/j.celr… #DBT #SERB #IISERs

Congratulations to Parik Kakani for identifying CTCF as a novel target of hypoxia. Hypoxia induces CTCF expression via TET2-mediated DNA demethylation and HIF1a binding, promoting EMT in breast cancer cells. Targeting the HIF1a-CTCF axis could offer new therapeutic strategies.

Finally, the wait is over. I’m excited to announce my first first-author paper from my post doc published in Cell Reports. Coauthored by Shruti Dhamdhere #Deepakpant #Rushikeshjoshi. Thanks Sanjeev Shukla and IISER Bhopal ERPLab@IISERB for your constant support. #CTCF #epigenetics

Parik Kakani ERPLab@IISERB

Congratulations Anchala Pandey

Interested in how epigenetic modifications impact alternative splicing in cancer? Join my lab at IISER Bhopal! We're exploring this exciting area with cutting-edge techniques. #cancerepigenetics #alternativesplicing #IISERBhopal ERPLab@IISERB

Old enemies, new perspectives? Explore the interplay of epigenetics and alternative splicing in cancer in this new review by @madhurapandkar from @erplab_iiserb, who is now a postdoc at Northwestern University; doi.org/10.1042/BCJ202… #Biochemj #iiserb

Preprint alert: Kudos to Deepak Pant from @erplab_iiserb for uncovering how YEATS2 & GCDH interplay drives histone crotonylation & EMT in #HNSCC. New mechanistic insights! #epigenetics #metabolism doi.org/10.1101/2024.0… IISER Bhopal

New preprint! Cheers to SRINIVAS ABHISHEK MUTNURU from @erplab_iiserb for revealing PRMT5-mediated histone methylation promotes EMT and invasion in breast cancer hypoxia by altering TCF3 splicing. #cancerbiology #hypoxia @iiserb doi.org/10.1101/2024.1…

Department of Biotechnology ERPLab@IISERB IISER Bhopal

Discover how #hypoxia fuels #breastcancer invasion! New insights into the #ATF3-#P4HA1 axis & #P4HA1 #alternativesplicing. Congrats Shruti Dhamdhere ERPLab@IISERB! Thanks @dbtindia IISER Bhopal. link.springer.com/article/10.103…

#authorinterview Shruti Ganesh Dhamdhere Shruti Dhamdhere ERPLab@IISERB IISER Bhopal talks about her work on "Adaptive stress response genes define invasiveness of hypoxic breast cancer" biopatrika.com/academia/resea… via Biopatrika

Exciting PhD opportunity! Join our lab ERPLab@IISERB (sshuklagroup.iiserb.ac.in) to explore the fascinating interplay of epigenetics & alternative splicing in cancer. Dive into cutting-edge research! Apply now: phdadmission.iiserb.ac.in #PhD #Cancer #Epigenetics #AlternativeSplicing

Congratulations, Anchala (Dr Pandey!!), on a successful PhD viva defense! So proud of you! 🙌 Wishing you all the best for the next chapter #proud mentor Anchala Pandey

Exciting work from Anchala Pandey and Jithin ERPLab@IISERB. Our latest study uncovers the SRSF9-BNIP3 axis, demonstrating how alternative splicing orchestrates both autophagy & metabolic reprogramming under hypoxia. IISER Bhopal jbc.org/article/S0021-…

Congratulations to Dr. Anchala Pandey Anchala Pandey, first author on our recent JBC paper! 🎉 She's off to a postdoc at the prestigious Wistar Institute & also received a Best PhD Thesis Award for her outstanding work at IISER Bhopal. Proud mentor!

A recent article from Dr. Shukla’s lab on “Identification of SRSF9 through pooled shRNA screening links BNIP3 splicing to autophagy and metabolic reprogramming in breast cancer ” is published in the Journal of Biological Chemistry. doi.org/10.1016/j.jbc.… IISER Bhopal