
Erik McShane
@erikmcshane
Father of two. @EMBOFellows in the Churchman lab @harvardmed. Fascinated by the role of RNA and protein degradation in gene expression control.
ID: 1168536566219694080
02-09-2019 14:50:10
186 Tweet
343 Followers
605 Following




Hi there! Our review on “Mechanotransduction in stem cells” is finally published. With Carsten Schulte we provided a comprehensive picture, that aims to cover the whole mechanotransductive pathway from the cell microenvironment to the nucleus. 1/3 pubmed.ncbi.nlm.nih.gov/38729084/


I love this video describing our work led by Erik McShane! Thanks to everyone who helped put it together. cell.com/molecular-cell…



So excited to see this review out 🤩 Had a lot of fun reviewing the field with @karine_choquet Autum Baxter Stirling Churchman. It’s been fascinating to see how far the field’s quantitative understanding of splicing kinetics has advanced in just the last few years 🧫🔬

If you’re interested in what the last few years have taught us about the process of splicing, check out our latest review!Congratulations to my co-authors Hope Eliana Merens @karine_choquet Autum Baxter





So excited to announce our new method for multiplexed RNA imaging in bacterial cells: bacterial-MERFISH! A huge congratulations to the team of Ari Sarfatis, Yuanyou Wang, and Nana Twumasi-Ankrah! Check out the following thread or our bioRxiv (biorxiv.org/content/10.110…) 1/12

🎉Our paper quantifying how RNA flows across subcellular compartments is published! 🎉 Read more in the preprint thread ⬇️ The paper contains an improved analysis of RNA flow rates and new collaborative work on DDX3X with @stephenfloor authors.elsevier.com/a/1jMoV3vVUPRm… Molecular Cell

Genome-wide quantification of RNA flow across subcellular compartments reveals determinants of the mammalian transcript life cycle authors.elsevier.com/c/1jMoV3vVUPRm… Published Molecular Cell Big thanks to fellow co-first authors Brendan Smalec Albert Xu @stephenfloor mentor Stirling Churchman +team!




Amazing work Eugenia Rojas (she/her/hers)! 🤩

Happy to share our latest manuscript on using quantitative proteomics to diagnose patients with mitochondrial disease. Great collaboration with Taylor Lab and Lukas Käll insight.jci.org/articles/view/…