🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

Happy to share my thesis work, now online at bioRxiv. We show that LDB1 organizes Enhancer-Promoter interaction networks and can function independently of cohesin! biorxiv.org/content/10.110…

Happy to share work with Maxime TORTORA on modeling the physical chemistry of cohesin loop extrusion! biorxiv.org/content/10.110…

Excited to see our paper officially out in the August issue of Cancer Discovery !

Speaker Spotlight: Marieke Oudelaar from the Max Planck Institute will share exciting research on the mechanisms behind 3D genome folding and its role in gene regulation during cellular differentiation. Don't miss it! Register here 👉 bit.ly/chromatin-2024 #chromatin2024

We then show these changes are found within tissues and during aging. To learn more, check out our preprint! Thank you to all co-authors, the Buenrostro lab, and everyone at HSCRB & Broad Institute who made this work possible! biorxiv.org/content/10.110…

📣Sharing the latest research from the Miguel Ramalho-Santos Lab, just released on bioRxiv! We found LINE1 RNA promotes nuclear compartmentalization to repress the 8-cell state in human embryonic stem cells. biorxiv.org/content/10.110… 👇Key findings:

1/🧬Does chromatin organization shape immune responses? Our recent study with Nick Adams led by Reizis Lab and Leonid Mirny explores how cohesin, a key player in chromatin loop extrusion, controls the chromatin architecture essential for conventional dendritic cells (cDC)👇

Excited to share a new preprint! (1)🔬The nucleolus is the most prominent nuclear condensate, with a fascinating multilayered liquid-like structure, and is the site of ribosome biogenesis. But how does this multiphase architecture form and function? biorxiv.org/content/10.110…

First preprint from the lab 🚨 How can enhancers regulate target promoters across vast genomic distances, and what is the role of cohesin loop extrusion in the process? biorxiv.org/content/10.110… (1)

Happy to share work with Hadi, Yao & Maxime TORTORA characterizing the impact of dynamic CTCF barriers for cohesin loop extrusion biorxiv.org/content/10.110…

🚨Inter-chromosomal contacts (‘kissing chromosomes’) organize human genome topology along a spatial gradient of genome activity (62 Hi-C datasets). Check rdcu.be/dZYQw, Nature Communications, 4DNucleome, The 3D Genome, Human Genome Org, Network Science Society, @Emblebi, @MoGen_Grads

It's my pleasure to present the next big preprint from SheqLab! An exciting application of our O-MAP platform that I hope will transform the study of nuclear architecture. If you've ever wanted to dissect the subnuclear "neighborhood" around an individual locus, read on! (1/30)

Congratulations Harshini Chandrashekar 💐 Using human neurons homozygously-engineered with familial AD mutations, she found a role for miswired promoter-enhancer multi-loops in dysregulated excitatory and inhibitory gene expression programs BioRxiv: doi.org/10.1101/2024.0…

Our paper discovering a centromere-localized retroelement RNA is now out in Genome Biology 🎉! Transcription of this retroelement is higher in CENP-A chromatin where insertions of this element seem to occur preferentially. Pls check it out and RT! genomebiology.biomedcentral.com/articles/10.11…

ft. Jailynn Harke, Jeewon Lee, Son C. Nguyen, Staci Rakowiecki, Rebecca Yunker, Doug Epstein, Eric Joyce (Penn Genetics), Arian Arab, @Melike_Lak (Penn Epigenetics) & Siewert Hugelier (UPenn Physiology) Molecular Cell cell.com/molecular-cell…

Excited to share our latest work on bioRxiv! Using cell-cycle dynamics and NIPBL depletion, we show that long-range enhancer interactions can form de novo without loop extrusion. Alternative mechanisms, including LDB1 and YY1, may play key roles.biorxiv.org/content/10.110…

Exciting news 📃🧬🔬 Today we report on the dynamics of a fascinating class of molecular motors, so-called SMC proteins in Cell doi.org/10.1016/j.cell…

We are deeply saddened by the loss of an esteemed colleague, friend, mentor & a pioneer in Drosophila & meiosis research. R. Scott Hawley was a dedicated supporter of GSA & a champion of genetics. Read an In Memoriam published in Genes to Genomes: buff.ly/3EoNQh8

Dr. Randi Isenhart (Randi Isenhart) has a new 1st author publication for her work in the Eric Joyce on: The length and strength of compartmental interactions are modulated by condensin II activity: dx.plos.org/10.1371/journa…