Nice work here by Sara El Zahed, Shawn French and team to take a hard look at the chemistry behind bacterial drug efflux. aac.asm.org/content/65/4/e…

Great fun to describe our journey in chemical and systems biology of bacteria for Accounts of Chemical Research. So fitting to co-author this work with my hugely talented Research Associates Maya Farha and Shawn French who have blazed this trail. pubs.acs.org/doi/full/10.10…

Scientists in Brian Coombes, PhD lab have identified a strain of bacteria as a possible trigger for #CrohnsDisease. "We are one step closer to figuring out how this ... bacteria lives in the gut and when we do that, we can develop new treatments." bit.ly/2QTZTtX

B.C. biotech company says, despite interim approval, provinces won't use its COVID-19 treatment cbc.ca/news/politics/…

Meet ‘Arcumycin’....Congrats Lydia! What a cool new lasso peptide that targets cell wall biosynthesis in Gram + bacteria...Discovery of the Class I Antimicrobial Lasso Peptide Arcumycin doi.org/10.26434/chemr…

Great fun collaborating with the Hung and Magolan groups on the discovery of new small molecule probes of the Gram-negative outer membrane. Tremendous leadership by Kristina Klobucar and a huge effort by J-P Côté! pubs.acs.org/doi/10.1021/ac…

Great work by Haley Zubyk that sets the record straight.

Exciting new work from Miller Lab lab and collaborators on better influenza vaccine development. McMaster Biochemistry & Biomedical Sciences McMaster IIDR Global Nexus

Super excited to see our study on the mechanism of action of the Gram-positive antibiotic armeniaspirol published in CellChemicalBiology today! dlvr.it/S48g88 Great collaborative project with @Pezackilab and Eric Brown. Incredible work by lead author Puneet Labana!

The National Microbiology Laboratory is recruiting for 9 positions including Technicians, Biologist I and II, Omics Inventory, IT Analysts, etc. canada.ca/en/public-heal…

Hisham Ziauddeen 😕

New preprint! Cool project driven by Liselot Dewachter who developed something we called sCRilecs-seq (subsets of CRISPR interference libraries extracted by fluorescence activated cell sorting coupled to next generation sequencing) biorxiv.org/content/10.110…

A life well-lived. We mourn the loss of our Founding President, Dr. Bob Murray (1919-2022). The Society stands as an enduring legacy to his vision of "a much-needed catalyst and unifier for the diverse applied and basic microbiologists of the country." amgfh.com/condolences/ob…

"Participants generally agreed that Canada should explore a pull incentive model to support antimicrobial access and innovation." sec. 1.4

Post-approval costs Financial Times "Isao Teshirogi, president of Shionogi ... which is also participating in the UK pilot with its drug, Cefiderocol. He says that maintaining its manufacturing plant for the drug will require about $100mn in revenue a year.” ft.com/content/29292a…

Our take on nutrient stress as an antibiotic target. Heavy lifting by my co-author Lindsey Carfrae. sciencedirect.com/science/articl…

Superb effort here led by Lindsey Carfrae to flesh out a cryptic but substantial role for fatty acid biosynthesis in colistin resistance. nature.com/articles/s4156…

Excited to see this work out today. Tremendous job by Ken Rachwalski and team in the Brown lab! A mobile CRISPRi collection targeting essential genes for genetic interaction studies in E. coli. cell.com/cell-reports-m…

Shawn French and team are 3D printing their way to new antibacterial chemical matter of unusual mechanism. Here, a semi-synthetic natural product (probably) hits the allosteric site of DNA gyrase. sciencedirect.com/science/articl…