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Happy to share my first preprint with @lacholt! We assessed how structure and disorder predictors behave differently for de novo and random proteins than conserved proteins. Turns out: Quite a lot! 🧵 1/10 biorxiv.org/content/10.110…

Our September issue is live! On the cover - a Review describing the molecular determinants influencing protein evolvability from Karol Buda Charlotte Miton Xingyu Fan Tokuriki lab. (Cover designed by Xingyu and Charlotte!) cell.com/trends/biochem…

Congratulations to my colleagues Dan Kehila and Kim Wong from the Tokuriki lab for this exciting review on the evolution of new metabolic pathways in microbial communities, out in Curr. Opin. Syst. Biol.! They hope to spark interest in these fascinating evolutionary scenarios!

Happy to share our new manuscript "Measuring differential fitness costs and interactions between genetic cassettes using fluorescent spectrophotometry". We developed a nice and easy way to determine fitness differences using a fluorescent plate reader. journals.asm.org/doi/10.1128/ae…

Are you interested how #epistasis shapes the AMR evolution? We showed that epistasis can be caused by independently modulating substrate binding and the chemical step ultimately changing the rate-limiting step in the catalytic cycle. Nature Catalysis nature.com/articles/s4192…

Excited to share our new preprint! We have done a comprehensive bioinformatic analysis of β-lactamases (all major five classes together). The work pretty much repaints our understanding of how β-lactamases are distributed in the environments. biorxiv.org/content/10.110…

Our exciting collaboration with the great Tokuriki lab on the biophysical basis for the malleability of trait correlation in single proteins (YFP and VIM2 metallo-β-lactamase) and on short evolutionary time scales. nature.com/articles/s4146…

Congratulations !!! Participating in the BMB Astell Award for EDI contributions is so exciting - each year we have the privilege to meet with awesome students (awardees and applicants) who have done so much for the community - this has been truly inspiring

Our latest manuscript "Understanding epistatic networks in the B1 β-lactamases through coevolutionary statistical modeling and deep mutational scanning" is out Nature Communications It is a great collaboration with Francesco Zamponi and Martin Weigt! nature.com/articles/s4146…

How can we effectively analyze and visualize massive protein sequence datasets to better understand protein evolution and function? ourANU bioRxiv "Exploring large protein sequence space through homology- and representation-based hierarchical clustering" • This

Paper from Matt and Dana (thanks to all other authors) published today nature.com/articles/s4225… Has been available via preprint - a few key points (I'm gonna run out of space...) in next tweet

Our new perspective paper, led by Sevan Gholipour and Dongkyu Lee, is out Biochemistry. We discussed molecular evolution and origins of antibiotic resistance genes" It is interesting to think how ARG evolved against natural vs synthetic antibiotics. pubs.acs.org/doi/10.1021/ac…