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science.org/doi/10.1126/sc… Excited to share our new work out today in Science Magazine, led by stellar postdoc Regina @hijaishin! We report the discovery of LYCHOS, a candidate cholesterol sensor for the mTORC1 kinase. Below is a brief summary of the story.

🚨New preprint🚨Hurley lab #CryoEM master Chen Cui Zhicheng Cui | 崔志成 presents the TFEBulator mega-complex. His structure identifies a non-canonical structural role for the Rag-Ragulator complexes in the phosphorylation of TFEB by #mTOR.

A new paper from Park Lab at UC Berkeley determined high-resolution structures of the human Sec61 channel inhibited by several structurally distinct small molecules and revealed the common inhibitor binding site. rdcu.be/dbVeo

Our work on the S1P transporter Spns2 is online Cell. The work was led by shahbaz ahmed Hongtu Zhao, and a wonderful collaboration with Xiaochun Li. We revealed the transport and inhibition mechanisms of this important sphingolipid transporter. authors.elsevier.com/c/1h7hYL7PXmcUZ

The #ShawPrize in #LifeScienceAndMedicine 2023 is awarded in equal shares to Patrick Cramer and Eva Nogales for pioneering structural biology that enabled visualization, at the level of individual atoms, of the protein machines responsible for #genetranscription. #ShawPrize2023

nature, researchers present cryo-EM and related data to show the mechanism that by which the TIM23 complex mediates protein import into mitochondria is not quite as was previously thought. nature.com/articles/s4158…