While we still don't know how subunit addition works, it's fun to think about all these tetramers coming together into a massive structure! The interior of the phage nucleus is quite negative, perhaps to keep that precious DNA inside. #phage #jumbophage #phagenucleus #cryoem

New preprint alert! Here we show how SEC-MS is a powerful tool for host pathogen interactions profiling. We applied it to Jumbophages, which are large bacterial viruses (>300 genes) holding great potential as antibiotics. What did we find? 1\n biorxiv.org/content/10.110…

Check out the latest preprint from @andreafossati9 and Deepto Mozumdar on using SEC-MS to identify protein:protein interactions during jumbo phage infections! Congrats, team! #phage #jumbophage #secms

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Our discovery of jumbo phage proteins that target host ribosomes right after infection out as a preprint. Global resource: new candidates manipulating transcription, protein synthesis, phage defense. CryoEM of our top candidate clamping 5S rRNA on the 50S. biorxiv.org/content/10.110…

Excited to announce deMULTIplex2 - a powerful new classification algorithm for multiplexed scRNA-seq data from the Gartner lab and Chan Zuckerberg Biohub Network, C3STC, and UC San Francisco developed by Qin Zhu & Danny Conrad: doi.org/10.1101/2023.0…

Browsing Zillow like a good millennial and I come across pseudomonas covered walls! 😱 Is this a new design trend? Is the #phagenucleus next?

Congratulations, Maru! Wonderful to see the final product come together 🎉

Thank you for the feature, Nature Communications! I had a lot of fun making this representation of the phage nucleus shell.

Hot off the presses...our coolest study ever...seriously! By comparing a thermophile, mesophile, and cryophile, we show conservation and ecological tuning of heat-triggered biomolecular condensation from the ecological to submolecular scales 🔥🔬❄️ (🧵) biorxiv.org/content/10.110…

Introducing Costasiella kuroshimae affectionately named the leaf sheep. This little dude not only crazes but can photosynthesise itself

We are hiring! Please spread the word. postdoctoral-ohsu.icims.com/jobs/26720/pos…

Are you in the St. Louis area, or willing to make the drive? Please join us in St. Louis on December 7th for an in-person symposium on cryo-EM at Washington University in St. Louis. Details can be found in the attached flyer. To register, scan the QR code found on the flyer.