BigSur: Statistically principled feature selection for single cell transcriptomics biorxiv.org/content/10.110…

Wow,UC Irvine is on a neuroscience hiring streak! Next up is a hard money tenure-track Asst Prof position UCI Neurobiology and Behavior for mol. neurobiol. of Alzheimer’s disease or other neurodegenerative disorders Apply starting Nov 1 to join our thriving group! recruit.ap.uci.edu/JPF09317

Next week at ASHG, please join my talk on a novel computational framework, CO-expression Module Perturbation Analysis for Cellular Transcriptomes (COMPACT), which can perform in-silico gene expression perturbations in single-cell data. Huge thanks to my co-developer Sam Morabito

Congratulations to my graduate student, Ze, for presenting their exciting research to a packed audience of over 500 at #ASHG24. So proud of your dedication and the impact of your work on advancing our understanding of genomics. Keep shining! #ProudAdvisor #ASHG2024

Congratulations to the whole team for this amazing tour de force work on spatial multi-omics in AD. nature.com/articles/s4158…

'#APOE Christchurch enhances a disease-associated #microglial response to #plaque but suppresses response to tau pathology' Kristine M. Tran, Nellie E. Kwang...Grant R. MacGregor & Kim N. Green UC Irvine UCI Charlie Dunlop School of Biological Sciences #AlzheimersDisease bit.ly/4h7SUoG

🧵"All biology is computational biology." That sounds bold. But it’s true. Here’s why: doi.org/10.1371/journa…

1/3 Metacells boost power in single-cell RNA-seq & multiome analysis. But without checking homogeneity, they risk forming dubious metacells that bias discoveries. We introduce mcRigor: a statistical safeguard for rigorous metacell analysis. 👉 nature.com/articles/s4146…

Did not know that… and it’s a really interesting finding.

Thrilled to share my poster at #ASHG25 in Boston! 🧠 In Silico Network Reprogramming of Oligodendrocytes Reveals Therapeutic Potential in Alzheimer’s Disease 🗓 Thu, Oct 16 | 2:30–4:30 PM | Board 4108T Come chat about network perturbation & therapeutic discovery in AD!

Fred Hutch Biostatistics is hiring (Asst/Assoc/Full Prof)! We seek scholars who lead with statistical thinking and connect computation, medicine & science across imaging, AI, genomics, clinical trials & cancer prevention. Apply by Dec 1, 2025: apply.interfolio.com/176402

Finally coming up for air from paper revisions & others 😅 Looking back on #ASHG25 — such an inspiring week! Learned a ton about foundation models and other ML models reshaping genomics, plus got to chat with Manolis Kellis and his team. Back to work 🧬