Out today: SCENIC+ is a comprehensive toolbox for inferring and analyzing enhancer-driven gene regulatory networks (eGRN) using single-cell multiomic data. @steinaerts Seppe De Winter Carmen Bravo nature.com/articles/s4159…

Incredibly proud to share our latest work (tinyurl.com/2wumvwsn) published in Cell. This is the fruit of my postdoctoral training with Brad Bernstein at Dana-Farber Broad Institute and Harvard Medical School. Now a thread about the science 🧵👇 #glioma #CELL #CancerResearch

Online Now: Early clonal extinction in glioblastoma progression revealed by genetic barcoding dlvr.it/St91WD

A short take on how computational approaches leverage multimodal single cell (RNA+ATAC) for inference of regulatory networks and a brief review of recent ground-breaking work by Dictys, SCENIC+ and MIRA by Luca Pinello @steinaerts Cistrome Data Browser et al. rdcu.be/disS3

Hey #sciencetwitter #mito #cancer ppl - pls RT - we've got two posts open in Payam A. Gammage lab @CRUK_BI UofG Cancer Sciences for postdoc fellows! One computational one wet lab - something for everyone :) check out beatson.gla.ac.uk/careers/postdo… & beatson.gla.ac.uk/careers/postdo… for more info. 👍🙂

Excited that veloVI is out Nature Methods! Led by Adam Gayoso & Philipp Weiler w awesome Yosef Lab, we combine deep generative modeling with a mechanistic single-cell transcriptional model for better RNA velocity analysis with uncertainty quantification. nature.com/articles/s4159…

RNA polymerase II associates with active genes during DNA replication nature.com/articles/s4158…

Tracking cell-type-specific temporal dynamics in human and mouse brains cell.com/cell/fulltext/…

Gliomas are among the most lethal and treatment-resistant human cancers. Listen to Sam McBrayer, an Assistant Professor at CRI, share how he and his lab are studying the way metabolism controls cell fate and cell function in the setting of #BrainCancer.

We are 60 years young and look forward to the next 60 years of molecular genetics at@MaxPlanckPress! We are celebrating with a scientific symposium and a ceremony on 30/31 May. Celebrate with us and register by April 30! Please share! #MPIMG60years molgen.mpg.de/60th-anniversa…

MultiRNAflow: integrated analysis of temporal RNA-seq data with multiple biological conditions academic.oup.com/bioinformatics…

OUT NOW in Cell Metabolism: CRI's @RJDLab, Dr. Zheng Wu & colleagues have have identified a new way to disrupt lung cancer growth. Read more: cri.utsw.edu/electron-trans…

Congrats Xun and MishraLab! Beautiful study, very happy to be able to contribute!

New in @sciencemagazine! Our study reveals how mutant IDH1 inhibition activates tumor immunity by inducing dsDNA sensing. Read more: science.org/doi/10.1126/sc… #CancerResearch #Cholangiocarcinoma #IDH1 1/n

Collab🚨: CRI's McBrayer Lab contributed to a discovery published in Science Magazine from Rob Manguso & Bardeesy Lab at Mass General Cancer Center that defines a new #cancer-causing mechanism associated with IDH1 mutations (the most commonly mutated metabolic gene across cancers). From

Join us! My lab UMass Chan Medical School is seeking postdocs and research associates who are passionate about how changes in metabolism and epigenetics contribute to cancer development and immune system evasion. DM me for a chat and apply at ummsjobs.com/job/10593/ (postdoc position)

Congratulations to Rumya Mirco J. Friedrich Daniel Strebinger Blake Lash Cyrus Biotechnology and colleagues on an exciting study combining AI and protein engineering to minimize the immunogenicity of Cas9 and Cas12a nucleases. These approaches have the potential to improve the safety and

Another great day for #relentlessdiscovery & #CancerResearch: SamMcBrayer received $1.19M to study developmental origins of IDH-mutant glioma in adolescents & Michalis Agathocleous received $900K to study the role of glutathione in leukemia development from CPRIT.

We report a new role for HIF in the regulation of endogenous retroviruses! It was a big collaborative effort to explore the HIF-mediated transcription, expression, and HLA presentation of ERVs in kidney cancer and leveraging them for immunotherapy cell.com/cell/fulltext/…

Today's #MondayMotivation is courtesy CRI's McBrayer Lab: Congrats Milan Savani for successfully defending your dissertation! Dr. Savani's family and lab mates joined to celebrate. Next steps: publishing his #research & finishing his M.D. UT Southwestern Medical Center 🎉 #relentlessdiscovery