Nice way to start 2023 :) Pleased to announce that our lattice light sheet study on B cell surface features and IgM B cell receptor localization is out in EMBO Journal. Many thanks to our collaborators, Bugra Özdemir, Michael Holtmannspötter, @KurreRainer, Ralf Reski 🇩🇪🇪🇺, PiehlerLab

Please RT: I am looking for a research assistant interested in the structural mechanisms of host-pathogen interactions. For more information, please follow the links below: wustl.wd1.myworkdayjobs.com/en-US/External… wustl.wd1.myworkdayjobs.com/en-US/External…

Very exited to share our recent study on Gasdermins now in Nature. Thanks and congrats to all co-authors! nature.com/articles/s4158…

Check out the beauty of nature from Liron's cool work😎 Congrats Liron and all the authors!

Ever wondered how inflammatory caspases recognize IL-1 cytokines for cleavage? Read more in our new paper, a collaboration between Jonathan Kagan and Prof. Hao Wu labs out today nature See🧵👇 1/ Harvard Medical School Boston Children's The PhD Program in Virology at HMS Harvard Micro nature.com/articles/s4158…

30+ years after caspases were found to be interleukin-1 converting enzymes (ICE), the first caspase-cytokine structure is revealed. We identify caspase-4 as a specific pro-IL-18 converting enzyme and describe the CryoEM structure of this enzyme-substrate interaction.

Pro-IL-18 is trapped by caspase-4 active site to be cleaved - I am proud to present paper that came out in Nature today by Pascal Devant Pascal Devant from Kagan lab Jonathan Kagan and Ying Dong @Ying70337209 from my lab. nature.com/articles/s4158…

The first time we see how cytokine is been captured by caspase, that is a mystery for over 30 years! Wonderful collaboration between the Kagan lab and the Wu lab. Big congrats to our team! nature.com/articles/s4158…

Thrilled to share our exciting paper on #NINJ1 published in Cell. NINJ1 acts as "🍪cutter" by cutting and releasing membrane disks leading to lytic cell death. doi.org/10.1016/j.cell… Congrats to the amazing team-Prof. Hao Wu Bobby Hollingsworth Jazlyn Borges @LabSteinberg

I am excited to share with you the Wu Lab Reunion video by Kara Jianing Fu! 27 featured structures and the 27-year journey! Seeing trainees from all over the world doing the best science is the ultimate reward as a mentor! I am proud!

Caspase-1 has a special way to interact with IL-18. So pleased to work with my long collaborator Hao Wu and new collaborator Lewis Kay on this project. Tweetorial by the fabulous Ying Dong: x.com/yingdong01/sta…

Take a look at our most recent collaboration with Prof. Hao Wu & Jonathan Kagan Labs! Jeff did some very cool NMR structural work of pro-IL-18 & contrasted it with Cryo-EM data and assays done by Ying Dong & Pascal Devant. Enjoy!