I would like to share the story of how a patient with cancer came up with the idea for a randomized trial, & how listening to him saved a lot of lives. 1/ In 2002, I had just completed a randomized trial with the notorious drug thalidomide for the cancer, multiple myeloma.

At Pillar VC, we’re open-sourcing all the knowledge and knowhow of building biotech companies. Today, we’re releasing the Pave + Founder-Led Bio Community compensation study. 🧬90 companies 🧫3.7k salary data points ✅industry-wide benchmarking founderledbio.com/biotech-compen…

(1/12) Very excited to share our new work in @VivianGradinaru lab at Caltech: Primate-conserved carbonic anhydrase IV and murine-restricted LY6C1 enable blood-brain barrier crossing by engineered viral vectors science.org/doi/10.1126/sc…. See the thread! #drugdelivery #BBB #AAV

Excited to share our preprint from the Ginty lab Harvard Medical School and Sharma lab Columbia University. Big shoot-out to the co-authors (Michael Iskols and others whose twitter not known to me). We hope the DRG neuron genetic toolkit can be a useful resource for the field. biorxiv.org/content/10.110…

My speech at the celebration of An's life.

John Hao… 6th Man! #Uno

Our lab (Viviana Gradinaru Lab) at Caltech (glab.caltech.edu and clover.caltech.edu) has multiple open positions, join us at the sunny south California! #apply through the 2 postings below: lnkd.in/g7QrKU3r lnkd.in/gShEdPsP

How do the ovary and the brain interact with each other? Eager to explore? Wish to find solutions for neuronal-related infertility? The Kahan lab is coming soon! PhD and MSc positions are open! anatkahan.wixsite.com/kahan-lab

Our lab (Viviana Gradinaru Lab) at Caltech (glab.caltech.edu and clover.caltech.edu) has multiple open positions, join us at the sunny south California! #apply through the 2 postings below: lnkd.in/g7QrKU3r lnkd.in/gShEdPsP (updated from prior posting)

Since the discovery of CRISPR-Cas systems, people have wondered if a similar type of system exists in eukaryotes. Today, we report in nature the characterization of Fanzor, a eukaryotic RNA-guided system that can be reprogrammed for human genome editing. nature.com/articles/s4158…

A glaring display of bad sportsmanship. Shuai Zhang’s opponent, Kiara Toth, erased a ball mark as Zhang was pleading to speak with a supervisor about a bad call “Wait, wait, keep the mark” Zhang was booed & retired from the match Awful. Just awful 💔

Intratumoral drug-releasing microdevices allow in situ high-throughput pharmaco phenotyping in patients with gliomas | Science Translational Medicine science.org/doi/abs/10.112… Excited to see this out!! Congratulations PPP Brigham and Women's Neurosurgery

Researchers discovered the blood-brain barrier in ants plays a pivotal role in shaping behavior. The BBB enzyme determines if ants forage or defend, offering insights that might apply to mice & beyond. neurosciencenews.com/blood-brain-ba… #neuroscience 1/2

Delighted to share the latest paper from The Robb Group in collaboration with Mikhail Shapiro (same on bsky) 🇺🇦’s group online now in PNASNews. Mechanophore activation using #biocompatible focused ultrasound! Huge congrats to Molly McFadden and Yuxing Yao and coworkers! doi.org/10.1073/pnas.2…

Marmosets have their siblings' microglia – not kidding about this: biorxiv.org/content/10.110…

Can we image intracellular calcium with ultrasound? Yes, w/ultrasonic reporters of calcium - URoCs! Congrats to Zhiyang Jin and co-authors on creating the first genetically encoded acoustic biosensors of this universal cell signal based on #gasvesicles. biorxiv.org/content/10.110…

Thrilled to share our new paper describing a novel form of neural computation: single cells drastically change their tuning in <20ms, shifting from a code for face detection to one that enables fine face discrimination. Neural dynamics are much richer than previously conceived!

This is a really fun collaboration with Rob Hurt and others! We hope everyone can use this and we are so excited to see how many new acoustic biomolecules this engineering platform would bring. Tell us what you are thinking and let’s make it!

Congrats to Caltech professors Viviana Gradinaru (BS '05) and André Hoelz!