Introducing Neuropixels Ultra, a new probe with >10x site density: an implantable voltage camera capturing complete planar images of neurons' electrical fields in vivo! ⬆️ spike sorting yield, ⬆️ detection of small fields and ⬆️ cell type identification.🧵 biorxiv.org/content/10.110…

We are looking for a research assistant to join the lab and work on spatial genomics. Please help spread the word—thanks! careersearch.stanford.edu/jobs/life-scie…

Today in nature, we report a spatial single-cell atlas of human cortical development, revealing surprisingly early specification of human cortical layers and areas. We built an interactive browser to explore the spatial data: walshlab.org/research/corte… Paper link below👇

A triumph of perseverance from twitterless Tom Weber, Christine Biben and the team, our in vivo barcoding "LoxCode mouse" used to resolve epiblast fate to fetal organs is finally published in Cell and available to import through The Jackson Laboratory sciencedirect.com/science/articl…

insane😡

The peer-reviewed version of expansion in situ genome sequencing is now out in Science! The news is bittersweet – when we first revealed this last September, I never guessed it would be my final paper in academia, but a lot has changed. A few parting thoughts:

This level of disrespect towards international talent is not really new. I vividly remember how humiliating my student visa appointment interview was many years ago. Now it's just being said out loud by the VP of the USA.

We are looking for talented postdocs/visiting students to join our team MIT Dept of BE and Koch Institute at MIT to innovate spatial multi-omics technologies, map clinical samples, and integrate AI/ML models to advance next-generation cancer immunotherapy. Please help to spread!!

Targeting DNA damage in ageing: towards supercharging DNA repair nature.com/articles/s4157… This new Review discusses approaches to pharmacologically mitigate the adverse effects of DNA damage to prevent mutation-driven cancers and mitigate age-related degenerative diseases

1/14 On behalf of the amazing team in Jonathan Weissman's Lab, we’re excited to share PEtracer (biorxiv.org/content/10.110…) a prime editing-based evolving lineage recorder compatible with both scRNA-seq and high-resolution imaging readouts in intact tissue. By applying PEtracer in a syngeneic mouse

Beautiful works🤩🤩

I’m relocating to NYC in early July 2025! Excited to catch up with old and new friends and chat about science. Let’s connect! ☕️

Our scMicro-C paper is out in Nature Genetics! Huge thanks to the reviewers for their valuable insights, to SunneyXie for unwavering support, and to fantastic collaborators Jiankun Zhang & Longzhi Tan. Thrilled to share this work!

I'm super excited to share that I will be joining the Department of Biology at Stanford University as an Assistant Professor in October 2025! I’ll also be a member of the Stanford Stem Cell Institute Stanford Stem Cell. Incredibly grateful to be starting my dream job!🧠🧬🖥️

A method for synthesis and assembly of megabase-scale DNA, along with an approach to deliver it into mouse embryos, offers a valuable tool for investigating de novo epigenetic regulation. nature.com/articles/s4159…

nature.com/articles/s4158…

From Silver to Gold🥇 Our advanced version of Gemini Deep Think has achieved the gold-medal standard at the 2025 International Mathematical Olympiad. It perfectly solved 5/6 problems in natural language with no expert intervention and that too within 4.5 hours!

New preprint! We solve a mystery you didn't know existed. Mitotic cells lack new transcription but require ongoing translation. Interphase mRNA half life is only 2-4 hrs. So how do cells arrest in mitosis for hours without depleting their transcriptomes? biorxiv.org/content/10.110…

Happy to share our work on how chromatin organization is established for the first time in early mouse embryos, in part via interplay with remarkable hypertranscription. Marvelous work by Guang Yu, Kai Xu, Weikun Xia and Ke Zhang! nature.com/articles/s4158…

Tremendous work by the extremely talented postdocs! Travis Lee Natanella Illouz-Eliaz 🎗️ Tatsuya Nobori .Thank you for putting in a major effort on this “side project” to develop a power community resource arabidopsisdevatlas.salk.edu