Excited to share our new work!!🥳How do cells lose totipotency to fate segregation? w Zernicka-Goetz Lab we found that early blastomeres experience a "Composite State" by displaying dual-lineages signatures! Link for full text👉: rdcu.be/dITfo

Congrats Nobu Hamazaki wei yang !!!

Very happy to share our latest w/ Devin Schweppe and Nobu Hamazaki labs, where we map the temporal dynamics and proteomic landscape of mammalian gastruloids. Sneek Peak 🧵below #stembryo #gastruloid #proteomics biorxiv.org/content/10.110…

🎉 Congrats!

7 years ago, I met a junior fellow named Jason Buenrostro who blew me away with a vision of futuristic genomic technologies Today, we (Ajay Labade, @carolinecomenho) are excited to share our first steps into that future: Expansion in situ genome sequencing 1/

Beyond stoked to share our latest, entitled “Diversified, miniaturized and ancestral parts for mammalian genome engineering and molecular recording” ! biorxiv.org/content/10.110…

We Yin Shen are excited to share our work on the functional characterization of enhancers of neuropsychiatric risk genes in human iPSC-induced excitatory neurons using CRISPR tiling deletion screening. biorxiv.org/content/10.110… 1/20

Genome engineering excelled at small nucleotide changes, but large edits remained challenging. Recent innovations are changing this. We reviewed the field of structural variant engineering Nature Genetics 🧬 Juliane Weller Thomas Vanderstichele @LeopoldParts nature.com/articles/s4158…

We are delighted to share the most recent work from our lab at Westlake University: ACSL4 and polyunsaturated lipids support metastatic extravasation and colonization: Cell cell.com/cell/fulltext/…

Absolutely beautiful work. Another milestone in cancer genetics and the Ventura lab! Congrats 🎉🎊🍾🎈

Now out in Science Magazine we present 'Genome-shuffle-seq': a method to shuffle mammalian genomes and characterize the impact of structural variants (SVs) with single-cell resolution in one experiment. science.org/doi/10.1126/sc…

I’m delighted to share our work on scrambling the human genome using prime editing, repetitive elements, and recombinases Science Magazine! Raphael Ferreira @LeopoldParts Tom Ellis, george church @SangerInstitute science.org/doi/10.1126/sc… Lots of changes from the preprint. A🧵