Exited to share a new review: Cisplatin in the era of PARP inhibitors and immunotherapy. A fun collaboration with Dr. Shuguang Leng’s lab at UNM Comprehensive Cancer Center UNM Comprehensive Cancer Center sciencedirect.com/science/articl…

New work from the @leunglaboratory! UT Health San Antonio UT Health San Antonio Research rdcu.be/dJzfA Evolved histone tail regulates 53BP1 recruitment at damaged chromatin in Nature Communications

The Cortez lab (lab.vanderbilt.edu/cortez-lab/) is looking for new postdocs or senior scientists. If you are interested in genome stability, replication, DNA repair, or DNA damage responses please send me an email.

One of the unforgettable moments at the 2024 Ion Channels GRC was the closing lecture by Fred Sigworth. If you missed it, here it is.. youtu.be/db1afWzokOU?si…

When overseeing grant review applications, one particularly grumpy reviewer pointed out why we should care about a mechanism when we know the approach works in the clinics. Exactly, why bother understanding how the engine works when the car still moves—until it doesn’t.

Nature research paper: Promotion of DNA end resection by BRCA1–BARD1 in homologous recombination go.nature.com/3ZkCJhG

Nature research paper: Mechanism of BRCA1–BARD1 function in DNA end resection and DNA protection go.nature.com/3zgF16U

#UTSW biochemist Zhijian "James" Chen, Ph.D., wins the Albert Lasker Basic Medical Research Award, sometimes called “America’s Nobel,” for his discovery of the cGAS enzyme, which senses invading pathogens and triggers immune response. bit.ly/3MQjHIr Lasker Foundation

I love this fundamental discovery science success story! Curiosity driven research birthed a new era of molecular medicine - congratulations and well deserved Drs. Ambros and Ruvkun! We need discovery and curiosity to remain a foundation of science.

Assistant and Associate Professor positions available at UPENN's Basser Center for BRCA . Great opportunity to be part of an amazing scientific environment. Assistant Level:  apply.interfolio.com/155257 Associate Level : apply.interfolio.com/155258

Join us in beautiful Ventura for the 2025 GRC meeting, Mammalian DNA Repair: Fundamental Mechanisms to Human Biology grc.org/mammalian-dna-……… Great program, including keynotes from David Pellman and Maria Jasin. We will be selecting talks and poster slots soon. Apply now!

BasserBRCA Penn Medicine - Abramson Cancer Center Penn Medicine Penn Medicine MD This is a great opportunity!

Online Now: PALB2 and 53BP1 govern post-resection homologous recombination DNA repair dlvr.it/TMD4rW

Earlier this year, I learned I have a pathogenic variant in BRCA2, which gives me a very high lifetime risk of breast cancer (55-69%), as well as an increased risk of ovarian cancer (12-29%) and pancreatic cancer (5-10%). 🧵1/ …