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Our latest work with Anna Nemudraia and Wiedenheft Lab is now available @bioRxiv! We show that #CRISPR-guided RNA breaks are repaired in human cells, and this RNA repair enables site-specific RNA editing. See the thread👇🏽 biorxiv.org/content/10.110…

Our study is on the cover! 😍

Now out in NSMB! How genome folding directs site-specific integration of phage DNA fragments into the CRISPR locus! Read here: rdcu.be/dmfSC Many thanks to co-authors for this collective effort! Thanks to Liz Kellogg ❄️🔬 and other reviewers for their thoughtful feedback!

I’m excited to share the preprint of my first first-author paper! The pandemic was a challenging time to start my PhD, but it spawned the awesome opportunity to join a second lab 800 miles west in Seattle to study ancient viruses in the human genome! 🧵👇

Our CRISPR-based RNA virus engineering study was covered in the latest #TWiV 1045 episode 🎙️🦠 Thanks Vincent MicrobeTV, Rich Condit, Brianne Dr. Brianne Barker, Alan, and Angela Angela R. Mingarelli for a very thoughtful discussion of our work!

Research at MSU has explored CRISPR immune systems and their role in DNA manipulation. In a new publication from researchers in MSU Micro & Cell Biology, that technology is applied to RNA using brand new methods. montana.edu/news/23165/

Thrilled to see our latest work published this week, on the essential roles of IscB/TnpB -- ancestral homologs of Cas9/Cas12 -- in transposon maintenance & spread. A wonderful team effort led by the talented Chance Meers! Thread on bioRxiv version below... nature.com/articles/s4158…

Montana State scientists publish research on CRISPR DNA bending montana.edu/news/23181/mon…

I'm excited to share our findings on a metal-dependent specificity switch for #CRISPR-Cas12a! We profiled the specificity of Cas12a at four Mg2+ concentrations and observed striking differences in mismatch tolerance at lower, physiological conditions 1/n biorxiv.org/content/10.110…

Out today in Mol Micro Editors: Inhibition of PQS signaling by the Pf bacteriophage protein PfsE enhances viral replication in P aeruginosa doi.org/10.1111/mmi.15… With our 🇨🇦 friends Eric Déziel and Karen Maxwell

New pre-print from the Sternberg Lab! Transposon-encoded nucleases (TnpB/IscB) gave rise to the CRISPR-associated proteins (Cas9 and Cas12), but were TnpB-like proteins domesticated for other functions? 𝙔𝙀𝙎!! doi.org/10.1101/2023.1…

Ringing in the new year with a pre-print on the PARIS defense system! This work defines how viral proteins activate PARIS-mediated tRNA cleavage and how viral tRNAs rescue infection. tinyurl.com/5x7epzxd. Also check out complementary work from the Corbett lab!

Truly great work from Amar Deep on the structure and function of the PARIS defense system!

Interested in #CRISPR? Check out this postdoc opening Andrew Santiago-Frangos, PhD lab!

Incredible seminar visit to Montana State University this week thanks to my generous host Will Henriques (grad student in Wiedenheft Lab that I’ve had privilege of co-mentoring past 4 years). First of all, Bozeman airport is one of the prettiest airports I’ve flown into

My lab is almost set up, and I'm looking for great people to join it! I am currently recruiting a research technician to drive an exciting project on molecular antagonism between bacteria and phage. If you're interested, DM me or apply to this position: wd1.myworkdaysite.com/recruiting/upe…

I'm excited to announce the start of my group Hör Lab Helmholtz Institute Würzburg (HIRI) in beautiful Würzburg! We'll study RNA phages, focusing on bacterial immunity and regulation 🦠🧬 Want to join us? Send me an email or find me at the conference in Boston next week!

New paper from the Wiedenheft lab! #CRISPR #RNA

Selfish genes rock!!! Click on the link to find out why. Thanks to all my coauthors for being incredible mentors. ⁦Wiedenheft Lab⁩ ⁦Harmit S. Malik⁩ ⁦@janet_young_123⁩ ⁦Artem Nemudryi, PhD⁩ ⁦Anna Nemudraia⁩ oup2-idp.sams-sigma.com/authorize?auth…

I am delighted to share the newest work from the Sternberg Lab, in which we discover RNA-templated gene creation as a mechanism of antiviral immunity. This is a story for anyone who loves molecular biology, and one that repeatedly left us in disbelief. doi.org/10.1101/2024.0…