Grateful for the renewal of my Canada Research Chair. And especially thankful to my terrific students and techs who make research so much fun!

Of all the meeting platforms we've used over the last 2 years, Zoom is the one I love most. Most of us think we know Zoom inside out. But we don't. Here are 7 Zoom hacks you probably haven't heard of, but you'll be glad you now know. 🧵👇

First in-person conference in over two years. The students did a great job representing the lab! Gordon Research Conferences

Lab picnic on the island. Fun but a bit chilly; maybe should have done it before the CIHR deadline...

#MDPIPharmaceutics "Plug and Pop: A 3D-Printed, Modular Platform for Drug Delivery Using Clinical Ultrasound and Microbubbles" by Kushal Joshi et al. Full paper at：mdpi.com/1999-4923/14/1…

Excited to share our work describing targeted transfection of injured lung. A huge effort by Rajiv Sanwal and collaborators. Over-expression of claudin-5 using ultrasound & microbubbles decreased vascular leakage w/o impairing innate immunity. journals.physiology.org/doi/abs/10.115… AJP-Lung Cellular and Molecular Physiology

Today we feature a #ShortReport in our #ArticleinPress by Rajiv Sanwal et al. #Ultrasound-guided transfection of claudin-5 improves lung endothelial barrier function in #LungInjury without impairing innate immunity: ow.ly/7jHo50OVYEG iBEST Unity Health Toronto University of Toronto

☝️Must read 👉LDL Transcytosis by the Arterial Endothelium—Atherosclerosis by a Thousand Cuts? 😉Inflammation stimulates LDL transcytosis 🤔Identifying the function and mechanisms of LDL transcytosis may ultimately permit its therapeutic manipulation doi.org/10.1007/s11883…

Directional Endothelial Communication by Polarized Extracellular Vesicle Release | Circulation Research Congrats ⁦Sneha Raju⁩ et al! Wonderful work from many labs ⁦Kathryn Howe⁩ ⁦Jason Fish⁩ ⁦Elena Aikawa⁩ ⁦WarrenLeeLab⁩ ahajournals.org/doi/10.1161/CI…

ApoAI/HDL binds and competes with LDL for SR-BI on endothelial cells, thereby partly reducing LDL transcytosis. Yet another way “good” cholesterol is beneficial. The last work from Karen Fung’s thesis and collaboration with my former neighbor WarrenLeeLab

Kothari et al found that large #HDL particles hinder #LDL endothelial #transcytosis. Read more about the implications for #CVD risk in type 1 #diabetes at ahajrnls.org/4636hBP Karin Bornfeldt Jenny Kanter @warrenleelab Tse Wing Winnie Ho Professrly Wobbrock 🧐

IL-1B accelerates atherosclerosis by inducing LDL transcytosis independently of caveolin-1. The pathway requires LDLR and Rab27a WarrenLeeLab Tse Wing Winnie Ho ahajrnls.org/3Aefewc

Delighted that Erika Jang and Winnie Ho's latest work is out. LDL transcytosis across the endothelium is the first step in atherogenesis, typically involving caveolin-1 and SR-BI or ALK1. We describe a distinct route that uses LDLR and Rab27a in response to pM levels of IL-1b.

Check out the latest #ATVBnet post by Liming Yu ! ahajrnls.org/3MQveaL

Agree with Mireille Ouimet. Really enjoyed CLVS2024! Great science and camaraderie.