Excited to share our preprint on how "teams" of epithelial & mesenchymal drivers inhibiting each other drive the landscape of large regulatory networks, thus driving canalisation of cell phenotypes biorxiv.org/content/10.110… Plz check out the thread (1/6) Gautam Menon Rik Thompson

This week in #MathOnco 1⃣9⃣4⃣: <life histories, network models of plasticity, model-informed precision dosing, coordination games, Hawk-Dove control theory, and more> thisweekmathonco.substack.com/p/this-week-in… Cover art by: Atchuta Srinivas Duddu & Kishore Hari 💯😎

PriSM (precision for integrative structural models) is now in press. It is an efficient method to annotate high and low-precision regions in integrative models. Varun Ullanat and Nikhil Kasukurthi did all the hard work, moving fast and breaking things! academic.oup.com/bioinformatics…

Happy to share our work on dynamics of coupled cellular decision-making feedback loops in Journal of Biosciences IASc, Bengaluru, led by Kishore Hari & Pradyumna Harlapur @BSSE_IISc, with contributions from Aditi & Varun Ullanat (BTech students RVCE Updates), Atchuta Srinivas Duddu. link.springer.com/article/10.100…

Predicting clinical outcomes of drug combinations from preclinical data is a major challenge Yepeng We know a drug works in the lab. But will it work in patients? 🔬 ➡️ 🏥 This is key for safe and effective therapies and it's one of the hardest challenges in medicine.

We introduce 🌿 MINT (Multimer Interaction Transformer) – a Protein Language Model (PLM) trained on 96M protein-protein interactions (PPIs) to predict binding affinity, mutational impacts, & antibody interactions better than existing PLMs. 🔗Code: github.com/VarunUllanat/m… 🧵👇