🧵 ANCA in Rheumatology: Tweet 1: ANCA — one antibody, many confusions. From GPA to drug-induced vasculitis, it’s powerful when used right… and misleading when used wrong. Here’s a quick guide 👇 Dr Ihab Suliman Dr. Akhil 🇮🇳 Dr Celestino Gutiérrez González MD 🇪🇸🍏🇻🇪 #MedTwitter #Rheumatology

Do we have it the wrong way around? Reduced GFR is cited as a reason to defer simultaneous initiation of #kidneyGDMT due to potential impact of acute 🔽 in GFR - but randomised data indicate diminished acute "dips" at lower GFR for RASi, SGLT2i & combo SGLT2/nsMRA Muthu Vaduganathan

✨Súper herramienta para ajustar la dosis del tratamiento antihipertensivo según: -Su potencia - mmHg deseados de bajada bpmodel.org #HTA #HTN #Hypertension

✅ PROGRAMA EDUCATIVO ANUAL DIALOGANDO CON EXPERTOS 👉 Lanzamiento del Comité Cardiorenal 🚀 Tema: UCR en latinoamerica: una realidad posible. 🗓️ Miércoles 10 septiembre 2025 🕖 19:00 Hs: 🇵🇦 PA ✅ REGISTRATE AQUI: bit.ly/slanh10septiem… 🌐 slanh.net

A beautiful "explainer" of everything a cardiologist needs to know about #eGFR in HF clinical practice with modern #GDMT ...and a plug to bring back #eGFRslope as an endpoint in HF clinical trials New in #EHJ with leading nephrologists Brendon Neuen academic.oup.com/eurheartj/adva…

Outpatient Worsening HF (Oral Diuretic Intensification) ☑️ Frequent ☑️ Prognostically meaningful ☑️ Temporally precedes 🏥 ☑️ Similar treatment effect sizes #GDMT as those on 🏥 Building evidence for its role in broader composite esp in lower-risk CKM pts academic.oup.com/eurheartj/arti…

My sense is that fewer HF patients will need loop diuretics in the future. I remember a decade ago arguing with a cardiology colleague whose approach was optimizing diuretics and sending patients for thoracentesis. He dismissed GDMT as pharma-driven polypharmacy. Today, many of

Sodium Retention in Liver #Disease: Is ENaC Activation Independent of the Renin-Angiotensin-Aldosterone System a Therapeutic Target? 🔗ow.ly/GobO50WxO3t ✍ Batlle D. et al. 📖#Nephron #SodiumRetention #Aldosterone

CKM (Cardiovascular-Kidney-Metabolic) Alphabet soup: GDMT in CKD from Daniel Edmonston #Nephpearls #NKFClinicals 🇺🇸 #Cardiorenal

Simultaneous or Rapid Sequence Optimization of Medical Therapy for Heart Failure: Time to Keep Score | Circulation: Heart Failure ahajournals.org/doi/full/10.11… Steve Greene

Hoy toca madrugar para ver el SURPASS CVOT #EASD2025 TRZ vs DULA ⬇️

2025 HF RCT Landscape 💊💉 HFpEF GLP1/GIP: #MARITIME sMRA: #SPIRRIT #SPIRITHF nsMRA: #REDEFINE ASi: #EASiHFPreserved IL6i: #HERMES HFrEF nsMRA: #FINALITY ASi: #EASiHFReduced Myosin Activator: #COMET Dig: #DECISION IV Fe: #ICONICHF All LVEF nsMRA: #CONFIRMATION MRmod: #BalanceD

🚨 Oral Semaglutide 25 mg delivers double-digit weight loss in OASIS-4 (Phase 3 trial) - - - Just out in NEJM: A 71-week RCT tested oral semaglutide 25 mg daily in adults with overweight/obesity (no diabetes). 📊 Results at 64 weeks: 🔹−13.6% mean weight loss vs. −2.2% with

Optimal glucocorticoid therapy in lupus nephritis 🔓doi.org/10.1093/ndt/gf… ➡️This review provides an in-depth analysis of glucocorticoid therapy for lupus nephritis, a severe manifestation of systemic lupus erythematosus that affects up to 51.7% of patients

Time to keep score of quadruple GDMT in HFrEF 1.2 million lives at stake each year

Glomerular filtration rate (GFR) is more than a biomarker! yes, it’s playful & dances in response to therapies but it is a direct reflection of kidney function its decline is a necessary intermediate to kidney failure thus is considered by regulators as an acceptable endpoint

New in European Society of Cardiology #EHJ Original article from #EPHESUS #EMPHASIS #BARCELONA studies 🔗 academic.oup.com/eurheartj/adva… Editorial with Brendon Neuen 🔗 academic.oup.com/eurheartj/adva…

⚡️ Glucocorticoid-Induced Osteoporosis (GIOP): 2025 Update ⚡️ •💊 Most common drug-induced osteoporosis → affects 30–50% of chronic GC users. •⏱️ Fracture risk rises in 3–6 months of therapy; risk not fully reversible post-discontinuation. •⚠️ Even low-dose pred (≥2.5

Full text is freely available if you want to learn about RV reserve from this extensive work lead by future ⭐️🫀 Peter Oro

SGLT2 inhibitors in CKD: 🤔are they really effective in all patients? 🆓 doi.org/10.1093/ndt/gf…