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Kellogg School of Management PhD Candidate Brandon Zborowski’s research interests are Financial Intermediation, Corporate Finance, Industrial Organization. Learn more about Brandon Zborowski & other Northwestern Economics Job Market Candidates at economics.northwestern.edu/people/phd-job…

1/ Thrilled to share an advancement in gene therapy from my PhD in Nature Communications! We've developed a new approach to reduce immune responses while maintaining efficiency—paving the way for safer, more effective therapies. Big thanks to Feng Zhang & Mirco J. Friedrich! bit.ly/redicas9

🚀 introducing fastppm: turbocharging tumor phylogeny reconstruction from bulk DNA-seq! we develop a new technique, tree-structured dual dynamic programming, to obtain 50-450x speedups for an important tumor phylogeny regression problem. check it out: biorxiv.org/content/10.110….

Congratulations to Eric and Wendy Schmidt Center postdoc Uthsav Chitra and team on their preprint, which introduces GASTON-Mix, an unsupervised deep learning approach for more accurately inferring spatial domains and gradients of gene expression: biorxiv.org/content/10.110… Broad Institute

2/ Here, wanted to highlight interesting approach from Bonnie Berger’s lab Massachusetts Institute of Technology (MIT), velorama Cell Systems. It goes the other way than regvelo, essentially leverages dynamics to infer regulatory interactions from single cell transcriptome and velocities, see cell.com/cell-systems/a…

At RECOMB-Seq, I will be presenting GLACIER, with Uthsav Chitra and my trainees Prannav and Huan Liang , where we introduce Spatial Granger Causal inference: decoding the drivers of tissue topology. It's a lovely RECOMB-to-RECOMB story, will tweet more soon. biorxiv.org/content/10.110…

I met Uthsav Chitra at RECOMB '22. We got lunch and talked science. His GASTON work (RECOMB '24), with its isodepth, was the missing piece for applying our DAG Granger Causality (RECOMB '23) to spatial settings. And thus GLACIER got going, led by Prannav Shankar and Huan Liang!

Excited to share our latest preprint, introducing the hierarchical cross-entropy (HCE) loss — a simple change that consistently improves performance in atlas-scale cell type annotation models. doi.org/10.1101/2025.0…

Congrats Youn! and team, Bonnie Berger Lab Hultgren Lab Broad Institute @mit Georg K Gerber Brigham and Women's Hospital Mass General Brigham Research Harvard Medical School Ashlee M Earl

🎉Congrats! 🥇Uthsav Chitra: Mapping the topography of spatial gene expression with interpretable deep learning 🥈Anurendra Kumar: CellWHISPER: Inference of contact-mediated cell-sell signaling 🥉Xinhe Zhang: An AI-Cyborg System for Adaptive Intelligent Modulation of Organoid Maturation

The White House Vision for Dismantling Science in One Simple Plot open.substack.com/pub/joshuaswei…