Congratulations to I3H members, Susan Weiss, (Vice Chair and Professor, Penn Microbiology), Dennis Discher (Robert D. Bent Professor, Penn Engineering), and our other esteemed Penn colleagues on being elected to the American Academy of Arts & Sciences. 👏

A next-generation “armored” CAR T cell therapy showed promising results in a small study of patients with B-cell lymphoma who had exhausted other treatment options ft. Carl June (Penn Path & Lab Medicine) & Jakub Svoboda (Penn Medicine - Abramson Cancer Center) Institute for Immunology and Immune Health (I3H) tinyurl.com/3ejw9334

Carl June and Bruce Levine of Penn Medicine—along with Isabelle Rivière, and Michel Sadelain (formerly of Memorial Sloan Kettering Cancer Center) have been jointly awarded the 2025 Richard N. Merkin Prize in Biomedical Technology for developing CAR T-cell therapy. Learn more: bit.ly/43G8kec

Join Institute for Immunology and Immune Health (I3H) on 6/18 for their Year in Review Symposium ft'ing keynote speaker Ruslan Medzhitov (Yale School of Medicine). Learn more➡️ tinyurl.com/298vrkbr

Spatial profiling of chromatin accessibility in formalin-fixed paraffin-embedded tissues ft. Pengfei Guo, Liran Mao, Chin Nien Lee, Xiaowei Xu, Yanxiang Deng (Penn Path & Lab Medicine), Yufan Chen, Angelysia Cardilla, Dengge Jin & Yucong Hua (Penn Engineering) nature.com/articles/s4146…

Mitochondrial complex IV remodeling plays a key role in how macrophages adapt to their surroundings—findings with major implications for #immunotherapy. Check out the newest study from Penn Medicine researchers published in Immunity.

A new study shows Cul5 helps prevent overproduction of certain blood cells by keeping key signals in check. A common drug may help restore that balance. Read the full JCI article ft. Paula Oliver (Penn Path & Lab Medicine) and colleagues.

"That was a transformational moment." Dr. David Porter reflects on a pivotal point in his career where the possibility of developing a treatment like CAR T cell therapy was just coming into view for him as a young physician-scientist.

The 2025 Colton Consortium for Autoimmunity Symposium united leaders from Penn, NYU, Yale and Tel Aviv University to share breakthroughs and chart the future of autoimmune disease research. Learn more: bit.ly/4oAxVif

Every revolutionary new treatment starts with a "first". Dr. David Porter recalls the moment he discovered that Bill Ludwig, the world's first CAR T cell therapy patient, had no evidence of leukemia just one month after his infusion at Penn Medicine.

Tune into the next session (9/16, 11AM ET) of the Colton Consortium Virtual Speaker Series—co-hosted by the Colton Center for Autoimmunity at Penn—ft. Mark Anderson, MD, PhD (UC San Francisco), a leader in #diabetes and #autoimmunity research. Registration required: bit.ly/AndersonSept16

Healthy blood cells can live without ARHGAP45—but acute myeloid leukemia cells can’t. 🩸 Junwei Shi, PhD, Associate Professor of Cancer Biology (Junwei Shi) and team show a CAR T + CDC42 inhibition strategy could target AML with minimal side effects. bit.ly/45OyXQu

Last week, Penn Medicine leaders cut the ribbon on a new home for #immunology research. The eight-story "overbuild" at 3600 CCB will house I3H, #ImmuneHealth, Colton Center for #autoimmunity, and related areas to foster interdisciplinary collaboration. youtu.be/Ryv2AxPtb_E?si…

More than 23.5 million Americans are impacted by autoimmune diseases. A new home opens as an epicenter for pioneering Penn Medicine research aimed at “breaking the immunological code” of these diseases and bringing them to heel. spr.ly/6015AyOIb

ft. Asmita Panthi, Max Ferretti, Olivia Howard, Rhiannon McCracken, Simon Boudreault, Mathieu Quesnel-Vallieres, Kristen Lynch (UPenn Dept of Biochem & Biophys), Swechha Pokharel, Sara Cherry (Penn Path & Lab Medicine) & Qin Li (Penn Genetics) sciencedirect.com/science/articl…

ft. Sam McCright, Olivia Harding, Julia Chini, Nicole DeMarco, Lisa Young, David Hill (@chop_research), Li-Yin Hung, Christopher Pastore (@PennVet), Joshua Rabinowitz (Penn IDOM) & Jorge Henao-Mejia (Penn Path & Lab Medicine) Institute for Immunology and Immune Health (I3H) Science Translational Medicine science.org/doi/10.1126/sc…

⏱️Every minute in the U.S., someone needs a blood transfusion due to their period. Dr. O’Neill + team are developing an mRNA therapy to treat abnormal uterine bleeding and uncover its causes—a potential breakthrough for menstrual health and #mRNA tech. bit.ly/4n8rGkB

🚨Congratulations to Prof. Dr. Carl June & Prof. Dr. Michel Sadelain! 2025 laureates of the Broermann Medical Innovation Award for the development of the CAR-T cell #immunotherapy #cancer #CancerResearch Penn Medicine Penn Medicine - Abramson Cancer Center pressreleasehub.pa.media/article/dr-car…

At 3600 Civic Center Blvd, E. John Wherry welcomed Good Morning Philadelphia to Penn Medicine's new hub for hundreds of researchers in immune health, infectious disease, population health data sciences, and others engaged in cross-disciplinary collaboration. bit.ly/4mmwd1w

Registration is open! Oct 3–4 @ PA Convention Center, Philadelphia. The 2nd Annual Advancing Precision Medicine Conference: "Advances in Precision Oncology: From Genomics to Targeted Therapies" is free and in person. Ft. Nobel Laureate Dr. Kaelin. bit.ly/48odQpH