Our updated #ubiquitin and #glycotime crossover paper is now online at The EMBO Journal. Want to see what we have added since the bioRxiv? Then head over there now and take a look! embopress.org/doi/full/10.15…

Very excited to share my first preprint where I report advances in understanding how activation of ALPK1 by ADP-heptose triggers an immune signalling pathway coordinated by the E3 ligases TRAF6, c-IAP1 and LUBAC #ubiqitin #ALPK1 biorxiv.org/content/10.110… MRC PPU UoD Life Sciences

Very happy to see my PhD work published 😊

Thrilled to see this research published! ALPK1 is a kinase activated by bacterial ADP-heptose, but disease-causing mutations allow it to also be activated by human metabolites, thereby leading to chronic signalling! pnas.org/doi/10.1073/pn… #ALPK1 #ROSAH MRC PPU UoD Life Sciences

📢 Are you interested in joining our lab in Copenhagen🇩🇰 as a #postdoc? We are an ambitious and friendly research group 👩‍🔬👨‍🔬 working on the regulation of #metabolism and #inflammation by #ubiquitin 🔬🧬. Project details and application link below👇 Please share!

Thrilled to have been awarded the Howard Elder Prize for my work on ALPK1😃. This kinase is activated by bacterial ADP-heptose, but mutations that cause a genetic disease and a rare cancer allow it to also be activated by human metabolites! #ALPK1 MRC PPU UoD Life Sciences

To restore cellular homeostasis, stress responses should be turned off at the right time and place. A paper @nature shows a ubiquitin-dependent mechanism through which unimported mitochondrial proteins silence the integrated stress response. nature.com/articles/s4158…

Congratulations to Tom Snelling and Jessica Oyie for receiving International Sponsored Places to attend the Biomolecular Horizons Congress 2024! We can't wait to hear about their experiences at this global forum celebrating the latest developments in bioscience and biotechnology.

An excellent postdoctoral opportunity to join Sapkota Lab to work on WNT signalling and colorectal cancer. We are looking for someone with a with a strong background in cell and molecular biology. To apply: jobs.ac.uk/job/DGS778/pos… MRC PPU UoD Life Sciences University of Dundee

Congratulations Elisha and Catriona: Professor Sir Philip Cohen's 50th and 51st PhD students awarded their degress ppu.mrc.ac.uk/news/elisha-an… Elisha McCrory Catriona

Congrats to Celest Tay Celest Tay & Oliwia Mruk Oliwia Mruk who received Highly Commended Awards in the Life Science category of the Global The Global Undergraduate Awards 2024. This was in recognition of their honours project research which both undertook MRC PPU buff.ly/4e8dIuI

Delighted to share our work in Nature Genetics using base editing to map genetic mechanisms of drug resistance. If you're interested in drug discovery then check it out. Access here rdcu.be/dXmlo [rdcu.be]. Congratulations to the team and Matt Coelho

Happy to share two protocols describing how to study #ALPK1 disease-causing variants using cell-based and cell-free kinase assays! They were used in our recent preprint on #ROSAH syndrome. (doi.org/10.1101/2024.0…) doi.org/10.21769/BioPr… doi.org/10.21769/BioPr… #UoDLifeSciences

JOB ALERT! MND Accelerator Award funded postdoctoral position in my lab MRC PPU is now LIVE. We will use pooled CRISPR screening of iPSC motor neurons to identify new targets for ALS/MND. To learn more & apply: ppu.mrc.ac.uk/careers/recrui… Please help spread the word! Thank you.

Now open – a CRUK-funded PhD clinical research training fellowship in my team at the Wellcome Sanger Institute. crukcambridgecentre.org.uk/education-and-…

How #autophagy influences the regulation of MHC-I class receptors and regulates #immune evasion of #cancer? A new role for an autophagy receptor IRGQ in this process with a clinical relevance for the development of liver carcinoma in humans and mice 😊😀 sciencedirect.com/science/articl…

Multimodal scanning of genetic variants with base and prime editing go.nature.com/3O6wQ0O

Quantitative Measurement of the Kinase Activity of Wildtype ALPK1 and Disease-Causing ALPK1 Mutants Using Cell-Free Radiometric Phosphorylation Assays: bio-protocol.org/en/bpdetail?id… Work by Tom Snelling at the University of Dundee. #Reproducibility #LifeSciences #Biochemistry

Available online - the Review "Diseases caused by altered specificity of a #proteinkinase for its allosteric activators" from Philip Cohen and Tom Snelling MRC PPU University of Dundee. #AtypicalAlphaKinase #ALPK1 #ROSAHsyndrom #Spiradenoma authors.elsevier.com/sd/article/S09…