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small RCT: Pramipexole 1 mg/d (agonist D2 r.) increased choice accuracy in the reward condition (reward learning) in healthy volunteers vs. placebo by preserving learned values. This is a plausible mechanism for pramipexole’s antidepressant effect biologicalpsychiatryjournal.com/article/S0006-…

Vitamin D toxicity is increasingly common given the emerging trend of high-dose OTC supplementation. Neuropsychiatric symptoms are like those of other hypercalcemic states (eg, confusion, apathy, drowsiness, depression, psychosis, stupor, and coma) psychiatrist.com/pcc/neuropsych…

Review: eating disorders affect 2% to 5% of individuals during their lifetime and are more common in females than males. First-line treatments of eating disorders include nutritional support, psychotherapy, and pharmacotherapy jamanetwork.com/journals/jama/…

RCT: Both vortioxetine and escitalopram improve cognitive symptoms in MDD, with escitalopram showing a modest cognitive advantage by the 4th week (MoCA scores; p=0.05) cureus.com/articles/32065…

SR - retro studies: 2/3 studies reported significantly decreased ADHD severity among TR monotherapy patients after switching to combined methylphenidate + atomoxetine. 3/4 studies reported greater adherence with combined therapy versus monotherapy cureus.com/articles/32637…

cohort study: Medical and recreative cannabis legalizations in US were associated with increases in CUD and cannabis poisoning diagnoses per 100 000 enrollees per quarter (all Ps <0.001) vs. states without these laws jamanetwork.com/journals/jamap…

El viacrucis de los colombianos retratado por el British Medical Journal. Un sistema de salud que necesitaba ajustes pero que mayormente cumplía, destrozado por los afanes ideológicos de los responsables de estas muertes. En su conciencia, si es que tienen una, pesarán.

We don’t have “better tests” for autism, we expanded the definition so much that it absorbed other conditions and personality traits. It is now a less reliable diagnosis. When someone uses the word autism, they could be talking about any number of individual difficulties.

Differential DNA methylation 7 months after SARS-CoV-2 infection A NEW study detected associations between changes in DNA methylation in individuals who had even asymptomatic or mild SARS-CoV-2 infections as compared to their household controls after 7 moths of infection 1/

A reminder that the regime in Iran is an unelected unrecognized unconstitutional death cult responsible for destabilizing and terrorizing the Middle East and the world.

En Medellín a esta hora. Y apenas arranca la #MarchaDelSilencio

La verdadera razón por la que Petro defiende al Hezbollah y a Irán. Y no. No son simpatías ideológicas.

Rewview: GLP-1r. agonists show efficacy in autism-related disorders, AUD, and depression without benefits in improving neurocognition or psychosocial functioning in SCZ, cocaine UD, or dementia. More well-designed, long-term studies are needed psychiatrist.com/pcc/efficacy-g…

A new review on neuroimmune pathophysiology of #LongCOVID explores how SARS-CoV-2 can cause lasting neurological symptoms through a combination of direct infection, immune dysregulation, and persistent inflammation. 1/

A NEW research analyzed multimodal MRI scans of 76 COVID survivors versus 51 healthy controls. The study found focal atrophy in the right basal ganglia and limbic regions, and decreased white matter integrity in tracts like the uncinate fasciculus and cingulum that was more

RCT: In patients with TRD, pramipexole augmentation up to 2.5 mg/d, demonstrated a reduction in symptoms (QIDS-SR16) vs. placebo at 12 weeks (MD= −3·91; −5·37 to −2·45). AEs with pramipexole: nausea, headache, and sleep disturbance or somnolence thelancet.com/journals/lanps…

Ojito con esto: El trastorno por dependencia a cannabis mostró relaciones causales bidireccionales con la mayoría de los trastornos psiquiátricos estudiados. El aumento del consumo de cannabis puede incrementar las tasas de trastornos psiquiátricos con el tiempo.

MRI study: Increased cumulative methylphenidate dosage was associated with increased gray matter volumes in several frontal areas in the early-exposure subgroup (baseline age ≤12 years) sciencedirect.com/science/articl…

Greater volumetric increases in frontal regions correlated with more improvements in oppositional symptoms. Conversely, the late-exposure subgroup (baseline age >12 years) showed no differences in cortical development or associations between methylphenidate and brain structure.

MA: Prescription of stimulants for ADHD was associated witha an average prevalence of past year misuse of 22.6%; past year diversion, 18.2%; and lifetime diversion, 17.9% frontiersin.org/journals/psych…