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🚨Out now in Blood Journal led by Tadeusz Kubicki We studied blood mass spec (EXENT) as an MRD tool post-transplant in myeloma. What made this analysis unique is that IgG M-proteins persist after destruction of the culprit cells due to recycling /1 #mmMRD doi.org/10.1182/blood.…

New paper out today in Blood Journal from the fantastic collaboration between Heidelberg University Heidelberg Myeloma University of Miami Memorial Sloan Kettering Cancer Center 🎉. Paper title: "The biological and clinical impact of deletions before and after large chromosomal gains in multiple myeloma" #msmm (1/x)

1/ IFM 2018-04 in Blood Journal! Ph2 🇫🇷 trial of "double" ASCT in high-risk #MMsm, not tandem per se. n=50, 60% UHR. 80% PFS at 2.5 yrs for HRMM! Similar to MUKnine. Much less dropout than BMT-CTN 0702... double > tandem for pt tolerability (if done)? ashpublications.org/blood/article/…

Myeloma is a curable malignancy #mmsm Yes it is curable The cure rate is not ideal (not all/most patients are cured)- there is still work to be done to improve We estimate that one out of three patients with standard risk myeloma (vast majority of cases) are cured 🧵

He was just being told how the academic publishing system works

COMy RWE from France confirms extramedullary disease still an unmet need despite CART as reported from RCT data by Nico Gagelmann Mohamad Mohty EMN we need specific trials for this subgroup Tomas Jelinek

Out now in Journal of Clinical Oncology! Our collaborative work: 𝐌𝐨𝐝𝐢𝐟𝐢𝐞𝐝 𝐒𝐭𝐚𝐠𝐢𝐧𝐠 𝐒𝐲𝐬𝐭𝐞𝐦 𝐟𝐨𝐫 𝐖𝐚𝐥𝐝𝐞𝐧𝐬𝐭𝐫ö𝐦 𝐦𝐚𝐜𝐫𝐨𝐠𝐥𝐨𝐛𝐮𝐥𝐢𝐧𝐞𝐦𝐢𝐚 (𝐌𝐒𝐒-𝐖𝐌) ascopubs.org/doi/10.1200/JC… Prashant Kapoor Shaji Kumar Vincent Rajkumar Jithma Abeykoon, M.D. Jonas Paludo A brief 🧵 1/

Join our summer school, 8-11th July in Brno! 4days full of #flow #cytometry and hands-on workshop. Detailed info & registration 👇👇👇 csac.cz/cs/kalendar-ak…

Very nice work! Important data ☝️Saurabh Zanwar

Congratulations to our great former student Nika Horková on winning the Prize for the best paper in basic research awarded by the Czech Society for Analytical Cytometry! csac.cz/cs/souteze/vys…

I always defended this agent as we observed very deep and durable responses in some of our patients. It is good to have this drug available, especially if the dosing might be once every two months in the future. Congratulations to the authors! nej.md/3wTS3pA

Here is a bit of history. Here is the original myeloma review that taught us the disease — prior to all the new drugs. From 1994. By Ray Alexanian & Thanos Dimopoulos nejm.org/doi/pdf/10.105…

Out now in Journal of Hematology and Oncology: Impact of Extramedullary Multiple Myeloma on Outcomes with Ide-cel: jhoonline.biomedcentral.com/articles/10.11… Shaji Kumar Yi Lin Krina Patel Surbhi Sidana, MD #dorishansen Moffitt Cancer Center BMC Top line results and a brief 🧵 1/

Finally out in Blood Cancer Journal! Amp1q worse than Gain1q. Gain1q may benefit from KRd+transplant. Additional copies of 1q induced transcriptomic changes. Isolated Amp1q is already bad but when other high risk features are present PFS<12 months! #mmsm nature.com/articles/s4140…

Congratulations ✊

Delighted to share our latest publication (Hoferkova et al., Leukemia):novel co-culture model inducing ~50% proliferation of primary CLL cells.The co-cultures mimic the gene expression of lymph node CLL cells + Pan-RAF inhibitors block CLL proliferation. rdcu.be/dKO3a

#IMS24happy to share that the 27th International Myeloma Meeting will be in Istanbul hosting minimum 3000 attendees

Congrats to Ondrej Venglar from our team Blood Cancer Research Group for Exemplary Abstract Award at #IMS2024 focused on monitoring of BCMA CAR-T cells using standardized flow cytometry assay! Lékařská fakulta OU Ostravská univerzita

One of the best things about our work is the people you get to know and learn from! Catarina Maia Juanjo Garcés Tomas Jelinek David Žihala were in our laboratory, gave their very best, and now are flying high in their work places. Friendship photographed in the last #ASH24 dinner

For those who want to carefully read and examine our GMMG-HD7 results from #ASH24 #mmsm Check out: ascopubs.org/doi/10.1200/JC… Big thanks to our patients and all collaborators! Heidelberg Myeloma Dept. of Hematology, Oncology, Rheumatology UK-HD