Happy to share a new article from my postdoc in Gareth Miles out in Journal of Physiology !! In this work, we describe a role for the M-type potassium currents, conducted by KCNQ channels in the differential control of motoneuron subtype recruitment. physoc.onlinelibrary.wiley.com/doi/10.1113/JP…

Predatory but generous at least 🤨

REVIEW - The T-type calcium channelosome - Here we compiled the current knowledge surrounding T-type #calcium #ionchannels interactors, their physiological roles, and potential for drug-based therapeutic intervention ➡️ rb.gy/2z7vdt

Just out our new research paper! We identify PIEZO2-dependent rapid pain system in humans and mice. The work led jointly by Otmane Bouchatta and Marek Brodzki in a close-knit joint effort of Saad Nagi and Szczot Lab groups. 🧵 1/10 👇doi.org/10.1101/2023.1…

POSTDOC POSITION - Pathophysiology of T-type #calcium #ionchannels in Slobo Todorovic' lab, Denver, Colorado 🇺🇸

A structural atlas of druggable sites on Nav #ionchannels T&F Channels ➡️ rb.gy/9jmbq3

Can you spot the mistake? 🤣

Check out our new review: Parkinson’s disease, epilepsy, and amyotrophic lateral sclerosis—emerging role of AMPA and kainate subtypes of ionotropic glutamate receptors. Maria Karela frontiersin.org/articles/10.33…

Fun opportunity to write a Perspective for Journal of Allergy and Clinical Immunology on the role of peripheral sensory neurons in immunomodulation. #Neuroimmunology Peripheral somatosensory neurons listen and orchestrate the immune response 👇 sciencedirect.com/science/articl…

A little rant about American universities, in the light on the recent Congressional testimony debacle: Today I learned that Harvard President Claudine Gay seems to have published only 11 peer-reviewed journal papers in her entire academic career. 'So what?', you might ask.

Fantastic lecture IOCB Prague this morning by Gerald Zamponi Zymedyne Therapeutics on targeting T-type #calcium #ionchannels in chronic #pain. Personally very happy to have you in Prague! 🙏

The final version of our Physiological Reviews editorial is published! Ion channel dysfunction is a hallmark for many diseases. Since ion channels are key therapeutic targets, we anticipate that unraveling new aspects of their dysfunction holds a huge potential towards novel treatments.

REVIEW - Pathophysiology of Ion Channels in Amyotrophic Lateral Sclerosis - Here we discuss the role of #ionchannels in #ALS #MND, their implications on neuronal excitability, and potential as therapeutic target. Credit and congrats go to Robin Stringer ➡️ rb.gy/c24uj9

Our paper on the mechanism of sensitisation of primary sensory neurons by DRG macrophages after nerve injury is out in GLIA Wiley Neuro ! onlinelibrary.wiley.com/doi/10.1002/gl…

#ionchannels #ALS #MND

Thanks to Philippe Lory @IGF_Montpellier for this nice Commentary on our recent Review "The T-type #calcium channelosome" #ionchannels ➡️ rb.gy/z1pmve

Very interesting chemistry leading to the design of a dual ligand of the α2δ-1 subunit of voltage-gated calcium #ionchannels and the μ-opioid receptor for #pain therapy ➡️ rb.gy/82y57e

New paper from the lab - Functional characterization of a novel de novo #CACNA1C pathogenic variant in a patient with neurodevelopmental disorder #calcium #ionchannels #channelopathies Charles University ➡️ rb.gy/9teu05

New paper in collaboration between Centre of Biosciences SAS & Charles University - Electrophysiological characterization of sourced human iPSC-derived motor neurons #ionchannels #mnd #als ➡️ rb.gy/5tdf7r

New paper in collaboration with Centre of Biosciences SAS & Charles University on the effect of #homocysteine on the excitability of hippocampal neurons #ionchannels #homocysteinemia ➡️ rb.gy/etbwoj