Congrats to Xinyao and Xie Chen! In eukaryotes, multiple transcription factors bind cooperatively to a regulatory region on genomic DNA to control gene expression. In this paper (bit.ly/3GV1BoP), we present an experimental metric for quantifying such cooperativity.

How do nucleosomes encode genome organization principles?nature Johns Hopkins Medicine "Native nucleosomes intrinsically encode genome organization principles" The research investigates whether individual nucleosomes contain sufficient intrinsic information for 3D genomic

"Native nucleosomes know where to go!” Our Condense-seq paper is now published in Nature! 📄 nature.com/articles/s4158… I’m deeply grateful to my PhD advisor Taekjip Ha and our incredible collaborators The Muir Lab , Bin Zhang , Erika Pearce, and Ben Garcia lab!!

Check out this tour de force study by Sangwoo Park and his incredible team of collaborators. Biophysical properties of single nucleosomes are responsible for A and B compartments in cell nucleus.

Amazing work from the HaLab, and this interplay between biophysical properties and genome organization are so cool! Congrats to Sangwoo and an amazing team.

New preprint on single-molecule mechanostructural fingerprinting! doi.org/10.1101/2025.0… We use DNA nanoswitch calipers to characterize the geometry and mechanical stability of telomeric DNA G-quadruplexes. #Biophysics #SingleMolecule #Mechanobiology #DNAnanotech

Commemorate the life and science of our dear departed colleague Jon Widom - this Thurs May 15 1230 pm in Pancoe Auditorium Northwestern MolBioSci Northwestern - our distinguished Widom Lecturer is Prof. Lucy Bai Penn State - Chromatin Accessibility and the 3D Genome

The Theoretical and Computational Biophysics Group is pleased to announce the 63rd "Hands-on" Workshop on Computational Biophysics (tcbg.illinois.edu/Training/Works…) to be held August 4-8, 2025 at Auburn University in Auburn, Alabama.

Proud to announce our new technique for tracking relative B cell clonality in situ with B Cell Receptor MERFISH (BCR-MERFISH)! Congratulations to Evan Yang and our colleagues in the Carroll laboratory! Check out our bioRxiv: biorxiv.org/content/10.110… 1/9

The secret to how nucleosomes shape the genome | Journal Club | PNAS pnas.org/post/journal-c…

Johns Hopkins neuroscientist Uli Mueller came to the U.S. for the chance to do research he couldn't do anywhere else. Now, he’s concerned those opportunities are slipping away as funding becomes less reliable. Read more: hub.jhu.edu/2025/05/21/us-… #ResearchSavesLives

Bringing the Genetically Minimal Cell to Life on a Computer in 4D biorxiv.org/content/10.110…

Congrats to HHMI Freeman Hrabowski Scholars Chantell Evans, Josefina del Mármol, Yvette Fisher and Theanne Griffith—named 2025 McKnight Scholars for their demonstrated commitment to neuroscience and dedication to mentoring others! 🌟 Congratulations to all the awardees! Read

Non-disruptive 3D profiling of combinations of epigenetic marks in single cells biorxiv.org/content/10.110…

DNA origami-based platform for multi-axial single-molecule force spectroscopy reveals hidden dynamics in Holliday junctions biorxiv.org/content/10.110…

high-throughput single-molecule platform to study DNA supercoiling effect on protein–DNA interactions academic.oup.com/nar/article/53…

Thanks TJ Taekjip Ha for giving me the opportunity to work on this, “Mechanistic insights into direct DNA and RNA strand transfer and dynamic protein exchange of SSB and RPA”academic.oup.com/nar/article/53…

🎉 Kicking off #Nucleic25 with an inspiring talk from Taekjip Ha on homology search in 3D genome - setting the tone for an exciting few days ahead! 🧬 🎉Our amazing poster presenters took the stage to introduce themselves and their work 🎉We wrapped up the day with a dinner full

So proud of the smashing success of the International Course in Biophysics co-organized with my UC Berkeley MCB colleague Carlos Bustamante The Bustamante Lab and University of Salamanca Universidad de Salamanca biophysal.org Course ends with a Keynote from Nobel Laureate Richard Henderson🥇

Know the editor: Sua Myong biophysics.org/blog/know-the-…