We are nearly ready for Options2024 1 MONTH TO GO! the full program (even as a pdf 😉) is available now! optionsxii2024.org.uk/programme/prog…

📣💡🤩 Speaker spotlight bios for our incredible for leaders in Flu++ research Keynote optionsxii2024.org.uk/programme/keyn… Plenary optionsxii2024.org.uk/programme/plen…

Pre-print your poster for Options including delivery to the conference! 🗓️📣To be submitted by Sept 25 Gosh that’s handy- thanks 🙏 optionsxii2024.org.uk/posters

Explore more of Queensland from Options- lots of day trips and local spots, or further afield For extra info check out 👇 optionsxii2024.org.uk/venue-and-loca… queensland.com/gb/en/home

Get in on the ground level of a new endeavor in The JCC Lab focused on comprehensive characterization of the human immune system throughout childhood development. The lab is hiring for a senior scientist focused on next-generation immunology. tinyurl.com/293nysxx #NowHiring

Antibody Fc receptor binding and T cell responses to homologous and heterologous immunization with inactivated or mRNA vaccines against SARS-CoV-2 Sophie Valk Nancy Leung 🦠 ⚔️ 💉 👨🏻‍👩🏻‍👧🏻‍👦🏻 Ben Cowling HKU Medicine Carolyn Cohen nature.com/articles/s4146…

Happy 10th birthday to the Doherty Institute 🦠👩‍🔬🧫 fun day to visit and celebrate the great work being done here

Happy #901Day, Memphis! Speaking of celebrating, my lab’s getting a facelift & I’m hiring: sr. scientist focused on applied integrative biology, sr. bioinformatics research scientist in integrative analysis, sr. scientist focused on next-gen immunology. tinyurl.com/jxezsb3k

New immunology insights for #LongCovid Key #SARSCoV2-specific T cell receptor signatures maintained to 2 years compared with unaffected control participants PNASNews Louise Rowntree Doherty Institute Kedzierska Lab @ProfPCDoherty pnas.org/doi/suppl/10.1…

#LongCOVID causes perturbations that persist from 12 wks to >2 years, but does this impact #Tcells? Our study pnas from @KedzeriskaLab @DohertyInst defines long COVID T&B cell responses over 24 mths from epitope specificity to TCR clonotype doi.org/10.1073/pnas.2…

With clinician collaborators in Melbourne & Hong Kong, we sampled COVID cases from their first SARS-CoV-2 infection, through their primary vaccination, over 24 months to track SARS-CoV-2 peptide–HLA tetramer-specific CD4+ & CD8+ T cells, and probe-specific B cells.

We found that antigen-specific T cells and B cells are established in people with long COVID and maintained over 24 months, similar to individuals without long COVID. These adaptive immune responses are stable and boosted by vaccination in people with long COVID! T cells 👊

We found robust SARS-CoV-2-specific T cells with effector phenotype & key TCR signatures (by time & epitope) 👇 in people with long COVID over 2 yrs following SARS-CoV-2 infection & subsequent COVID-19 vaccination, suggesting that T cell responses are unaffected by long COVID.

Reassuringly in long COVID samples frequencies of ORF1a- & nucleocapsid-specific T cells (i.e. virus targets not in vaccine) remained stable over 24 months, indicating long-term persistence of SARS-CoV-2-specific memory pools in long COVID. Flu-T cells were not impacted 😅

This study by Louise Rowntree & Jennifer Audsley, led by @ProfPCDoherty, Irani Thevarajan, @svalk03, Katherine Kedzierska & Oanh Nguyen, conducted Doherty Institute, UniMelb MDHS, University of Melbourne in collab with The HKU-Pasteur Research Pole & CUHK Medicine 🏥🩸

With thanks to our many fantastic collaborators incl @SharonLewin & Prof. Jamie Rossjohn, and our fabulous patients and nurses 👏👏👏. Our work was supported by NHMRC, APPRISE for SETREP-ID, Snow Medical, Jack Ma Foundation, TRS RGC & Narvie McConneaughey 🌟🌟🌟

So excited to see our new study on #Tcells in #LongCovid published today in PNASNews. Big thank you to Oanh Nguyen, Sophie Valk and Katherine Kedzierska for championing the work.

Grateful to have our RCT of third dose COVID vaccines long term immune correlates highlighted by Nature Communications on the Editors selection in “Microbiology and Infectious diseases” section- in great company! nature.com/collections/je… nature.com/articles/s4146…

Here Options2024 for a superb conference and great to see that Antoni Wrobel plugged our paper on the bat influenza H17 receptor.

🏆🦆A huge congratulations to Dr Michelle Wille from University of Melbourne and Doherty Institute for receiving the coveted @aipolsci Victorian 2024 #YoungTallPoppy Science Award recognising her research in avian influenza go.unimelb.edu.au/5o78 Michelle Wille UniMelb MDHS The Royal Melbourne Hospital