A fascinating work is published today nature by Zhang & Zhang et al. on a serendipitous discovery of haemoglobin expression outside the RBC cells--in chondrocytes--and their critical role in keeping our cartilage alive under an oxygen-deprived environment.

Terrific work by Debalina Datta, Ambuja Navalkar and MajiLab (Protein Engineering and Neurobiology Lab) showing p53 phase separation might regulate its life cycle and function. Thanks to SERB, IIT Bombay, Biosciences & Bioengineering, IIT Bombay for support and Kundan Sengupta for STED microscopy biorxiv.org/cgi/content/sh…

Exciting news! Our latest preprint on determining surface charge of condensates using microelectrophoresis is available to read now on ChemRxiv! Check out the research by Merlijn here: chemrxiv.org/engage/chemrxi…

Happy to share the publication of our paper in nature Conformational ensembles of the human intrinsically disordered proteome Work led by Giulio Tesei and Anna Ida🕊. I'll post more later, but for now here is a link: nature.com/articles/s4158… and a short movie about the work

How do proteins mis-fold? New preprint led by Jacob Aunstrup from Alexander Buell @biophysics_dtu group with MD simulations by Abigail Barclay. We combined experimental measurements of Φ-values with restrained simulations to study the TSE for fibril growth doi.org/10.26434/chemr…

Phase Separation and Aggregation of α-Synuclein Diverge at Different Salt Conditions dlvr.it/T3YxSM

In this comprehensive review now published in The Journal of Chemical Physics , Alex (@biophysics_dtu) and I highlight the recent advances in the experimental methods to quantitatively study biomolecular phase separation. Really happy to finally see it online! doi.org/10.1063/5.0190…

THEY SAID WE COULDN'T DO IT........well, no one actually said that. But in our updated manuscript with Casper Goverde, Nico Goldbach, and Bruno Correia we show you can now design soluble analogues of membrane proteins with preserved functional features! biorxiv.org/content/10.110…

Our paper on swimming active protein droplets is finally out! 🎊🎉 nature.com/articles/s4146… The main result is in the title: "Phase-separated droplets swim to their dissolution". Explanations below 🧵👇 Laboratory of Soft and Living Materials ETH Department of Materials Cornell University CNRS Ingénierie Nature Communications

Check out our newest publication on creating custom architectures inside biomolecular condensates - congratulations Nadia, Daoyuan Qian, Tomas and others together with the Weitz lab and van Hest Lab! nature.com/articles/s4428…

Want to measure the volume fraction of biocondensates or coacervates? We present easy and accurate methods, with which we found that upon destabilization, condensates can either shrink or swell, giving insight in condensate volume regulation in cells. chemrxiv.org/engage/chemrxi…

Rapid and reversible dissolution of biomolecular condensates using light-controlled recruitment of a solubility tag: nature.com/articles/s4146…

Our latest preprint is now live on bioRxiv! We demonstrate how to control α-synuclein adsorption, desorption, and aggregation at charged biomolecular condensate interfaces. Check it out here: doi.org/10.1101/2024.1…

I arrived in Tokyo to reunite with my better half Samrat Mukhopadhyay after 1.5 months & excited to see our latest paper published in The Journal of Physical Chemistry in which we show protein aggregation/disaggregation by Hofmeister cations. Congrats, Deepika Thapar Institute of Engineering & Technology. pubs.acs.org/doi/10.1021/ac…

Our new preprint on stability of alpha-synuclein fibrils and their disaggregation by chaperones is out!! The chaperones effectively disaggregate 3/4 fibril types with varying efficiencies that correlate with their thermodynamic stability. biorxiv.org/content/10.110…

Synthetic biomolecular condensates enhance translation from a target mRNA in living cells: nature.com/articles/s4155…

PhD position alert 🚨. I have a fully funded PhD position in my group at DTU-Bioengineering. If you want to work with protein phase separation and aggregation in neurodegenerative diseases, this could be a great opportunity for you. Apply here: efzu.fa.em2.oraclecloud.com/hcmUI/Candidat…