Watching #coronavirus replication! #SARSCoV2 polymerase-RNA structure: basis to study potential #COVID19 drug #Remdesivir Team Hauke Hillen Goran Kokic Lucas Farnung Christian Dienemann Dimitry Tegunov @mpi_bpc Max Planck Society Preprint biorxiv.org/content/10.110… PR mpibpc.mpg.de/17275755/pr_20…

PenguiN, our viral metagenomics assembler, just got accepted at BMC Microbiome! In contrast to the standard de Bruijn graphs assemblers, it uses all-vs-all alignment in linear time to merge reads. This allows it to often resolve severalfold more strains than dBG assemblers.

Example: The number of full-length ssRNA phage genomes assembled from 82 metatranscriptomic samples from activated sludge and freshwater (Callanan, J. et al. Science Adv, 2020). PenguiN assembles ~3x more genomes (at 99% seqid filtering) than the next best assembler.

See PenguiN manuscript at biorxiv.org/content/10.110…