Whole genome sequencing (WGS) vs. whole exome sequencing plus array genotyping and imputation (WES+IMP), which one is more cost-effective for population-scale genetic association studies? My colleagues at Regeneron Genetics Center (Gaynor et al.) answer this question using a

I'm delighted to release the first half of my new open-access online textbook in human population genetics: web.stanford.edu/group/pritchar…

Episode 114 of The Genetics Podcast is live! 🚀 In this episode, drug discovery scientist Veera Rajagopal  shares his 2023 round-up. Tune in to explore: 🔬 Casgevy approval 🧪 APOL1, APOE4, FTO & more 🌏 The rise of global genomics Listen here 👉pod.fo/e/20d757

WE ARE HIRING The biostatistics unit Human Technopole is looking for a junior analyst to help us understand the genetic bases of complex traits focusing on new methods and implementations. We can offer top-notch science and a cool working environment. shorturl.at/dmKV2

We work on a wide variety of projects ranging from large scRNA datasets to disease in perspective each with its own challenge and approach. So come join me Sodbo Sharapov and Arianna Landini here in Milan! Don't hesitate to contact me through mail or DM for more info.

Great to be finally back at EMGM2024 meeting after many years!

On our way to the European Society of Human Genetics (ESHG) 2024. Looking forward to an amazing conference with this brilliant team from Human Technopole : Federica Santonastaso Sara Ometto Craig Glastonbury Sodbo Sharapov Andrea Corbetta Michela Massi and others..

Phenomenal work on multi-ancestry QTLs! "97.5–99.8% of credible sets had similar effect sizes between pairs of continental groups" nature.com/articles/s4158…

A Bioinformatician, Computer Scientist, and Geneticist lead bioinformatic tool development - which one is better? biorxiv.org/content/10.110… Affiliations with "bioinformatics" and "engineering" are less "accurate", but not statistically significantly so.

Excited to share our work published in Nature Human Behaviour! 🚀 We conducted a GWAMA study on 12,000+ individuals, analyzing 184 neuro-related proteins for genetic links and causal effects on mental health. doi.org/10.1038/s41562…

I am truly humbled to be asked to speak at a TEDxLakeComo event in November

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In absolutely perfect timing for #ASHG24 I am so pleased to announce the labs second manuscript that was entirely conducted Human Technopole. Here we showcase the power of diffusion autoencoders for phenotyping time resolved cardiac MRIs in 70k subjects. medrxiv.org/cgi/content/sh…

Beyond genomics, single-cell RNAseq also shows relevance for drug target selection❗️ Targets with 👉high expression in disease-relevant cell types OR 👉cell-type overexpression in disease patients are more likely to proceed in clinical development💊 🔗medrxiv.org/content/10.110…

You will never forget what m and n stand for with this one

bsky.app/profile/sodbo.…