This review discusses #VEGF ligands and receptors, their molecular mechanisms, evaluates recent advances in VEGF-targeted therapies, and highlights the translational potential of new discoveries in VEGF biology. Sookmyung Women’s Univ. #STTT #OpenAccess: doi.org/10.1038/s41392…

An overview of the structure and components of #platelets, their signaling pathways, and biological functions, with highlights on their diverse physiological & #pathological roles as well as their therapeutic potential. #STTT #OpenAccess: doi.org/10.1038/s41392…

Targeting IFNγ-mediated #pyroptosis reverses PA-induced downregulated antitumor immunity of γδ-T cell antitumor immunity, while dietary OA improves responsiveness to Vγ9Vδ2-T cell-based #immunotherapies. The University of Hong Kong New study in #STTT #OpenAccess: doi.org/10.1038/s41392…

A review on copper homeostasis, its pro- & anti-tumorigenic roles, the molecular mechanisms regulating cuproptosis, as well as the potential of copper- or cuproptosis-based therapies for cancer treatment. #STTT #OpenAccess: doi.org/10.1038/s41392…

Neoadjuvant anti-#PD1 antibody tislelizumab plus #chemotherapy shows promising antitumor efficacy and a tolerable safety profile in patients with stage IB3/IIA2 locally advanced cervical cancer (#LACC) #OpenAccess: doi.org/10.1038/s41392…

This review outlines the epidemiology of #virus-related #tumors, explores the molecular mechanisms driving tumorigenesis, summarizes current therapeutic strategies, and highlights recent advances in preclinical and clinical research. #STTT #OpenAccess: doi.org/10.1038/s41392…

Replication-competent vaccinia Tiantan-based #HIV candidate vaccine combined with a #DNAvaccine component exhibits promising safety & tolerability profiles while eliciting a robust #ImmuneResponse against #HIVantigens. #STTT #OpenAccess: doi.org/10.1038/s41392…

This article outlines the role of #ProteinKinases in #neurodegenerative diseases, reviews the progress of kinase inhibitors in #ClinicalTrials, and discusses the challenges & future directions of kinase-targeted therapies. Huazhong University of Science and Technology Sichuan University #STTT #OpenAccess:

This study reveals the dual role of SRSF1 in #tumorigenesis, showing that its inhibition by the novel inhibitor TN2008 restores CD8+ T cell function, and boosts immunotherapy, highlighting it as a promising #CancerTherapy. #STTT #OpenAccess: doi.org/10.1038/s41392…

A review on the epidemiology of high-risk HPV (hr-HPV)-related cancers, the lifecycle and the oncogenic signaling pathways of hr-HPV, with a discussion on its role as a #Biomarker and anti-cancer #TherapeuticTarget. #STTT #OpenAccess: doi.org/10.1038/s41392…

Researchers show that targeting VCP in combination with anti-PD1 therapy significantly suppresses #HCC growth & restores CD8+T cell anti-tumor function, positioning VCP as a promising upstream target for enhancing #immunotherapy in HCC. #STT #OpenAccess: doi.org/10.1038/s41392…

This #STTT study characterized the serum neutralization against primary Omicron variants in the sera of vaccinated individuals, demonstrating that recombinant XBB1.5 induced high neutralization titers against JN.1 sublineages. #OpenAccess: doi.org/10.1038/s41392…

SMYD3 interacts with & methylates c-MYC, influencing colorectal cancer carcinogenesis and stemness genes expression. Therefore, targeting SMYD3 may inhibit proliferation & c-MYC-dependent metastatic dissemination. #STTT #OpenAccess: doi.org/10.1038/s41392…

This review explores the development and structure of #MeningealLymphaticVessels, methods for their observation, functions, molecular mechanisms of injury, links to #CNS diseases, & potential regulatory mechanisms. Chinese Academy of Sciences #STTT #OpenAccess: doi.org/10.1038/s41392…

Scientists identify GPR133/ADGRD1 as a key regulator of #osteoblast function & bone formation, where activation with AP503 alleviates osteoporosis in mice, positioning it as a therapeutic target for #osteoporosis. @unileipzig 山东大学 SHANDONG UNIVERSITY #STTT #OpenAccess:

This #STTT review summarizes the complex mechanisms underlying the pathophysiology of diabetic nephropathy (DN), outlining recent advances in diagnostic & therapeutic strategies and future directions for managing DN. #OpenAccess: doi.org/10.1038/s41392…

This study reveals that TPM3P9 promotes #tumor growth in #ClearCellRenalCellCarcinoma (ccRCC) by enhancing the #alternativesplicing of oncogenic RNAs and highlights it as a potential therapeutic target in ccRCC management. Jinan University #STTT #OpenAccess: doi.org/10.1038/s41392…

Evaluation of the efficacy & safety of adding pyrotinib to a neoadjuvant regimen of trastuzumab & chemotherapy in HER2-positive breast cancer patients showed that Pyrotinib elicits a beneficial response. Qingdao University #STTT #OpenAccess: doi.org/10.1038/s41392…

Describing the role and mechanisms of metal ions in brain #homeostasis and #Neurodegenerative diseases, with a discussion on the therapeutic implications of metal ion chelators in neurodegenerative diseases. Qingdao University #OpenAccess: doi.org/10.1038/s41392…