Servus Munich! 🥨 🍺

No better way to end a day that began with „Daddy, I have a pebble stuck in my nose“ and me channeling my inner otolaryngologist with sailing on beautiful Ammersee with the Alps in the background 🏔️ ⛵️

This will only be effective if EVERYONE refrains from tweeting (X-ing?) on August 1st a/k/a #TweetlessTuesday. Let's show the owner the POWER OF THE PEOPLE. Honestly, would it kill you to keep your thoughts to yourself for 1 damn day? Read a book! 👀 #August1stTweetOutDay

Persistence of #SARSCoV2 spike protein (red) in the skull bone marrow and meninges, an immune reservoir niche at autopsy in people who had Covid, work by Ali Max Erturk and colleagues

Really proud about our recent JASN_News paper. The team around first author Max went through a tour de force on transferring our #zebrafish FSGS model into a high-content screen. Furthermore, the initial drug screen identified HDAC inhibitors as effective in the FSGS model. 🎉🥳

Exciting news! APPLAUSE IgAN proves that iptacopan is effective in lowering proteinuria in IgAN. Finally, we will have a specific therapy for IgAN. novartis.com/news/media-rel…

BREAKING NEWS The 2023 #NobelPrize in Physiology or Medicine has been awarded to Katalin Karikó and Drew Weissman for their discoveries concerning nucleoside base modifications that enabled the development of effective mRNA vaccines against COVID-19.

Amazing press release from Eloxx Pharmaceuticals about NIPOKA cooperation in Alport syndrome treatment.Our Precise Podocyte Morphology Procedure (PEMP) has shown a 60% increase in Filtration Slit Density (FSD) after ELX-02 treatment, underscoring its impact in medical research

Toxicologic autumn walk with the 3yo. 🍄

Double paper alert 🚨 this week: 1. in cooperation with Levtchenko's Lab we investigated cystinosin mRNA therapy for treatment of cystinosis in #zebrafish—> improvement of both tubular and glomerular #kidney dysfunction 🎉 nature.com/articles/s4159…

Publication 🚨: In #zebrafish and with the help of PEMP NIPOKA we helped to establish that inhibition of the glucocorticoid receptor could be a novel treatment approach for nephrotic syndrome potentially bypassing adverse steroid side effects. Thanks Stamellou Eleni!

CODA reconstructs arteries and arterioles in the developing kidney from registered stacks of H&E slides automatically annotated using a trained deep learning algorithm. More here: biorxiv.org/content/10.110… Led by PhD student luciedequiedt.bsky.social and Prof. Ashley Kiemen from Johns Hopkins Pathology

FSGS results in loss of filtration barrier function and the development of sclerotic lesions. This study developed a novel in vivo HCS assay that identified belinostat and related pan-histone deacetylase inhibitors as potential candidates for treating FSGS bit.ly/JASN0235

And I thought the wave of pus that I saw flowing towards me in a patients auditory canal last week was the most disgusting thing ever. But hell no. 🕷️🥴

Flashback #FluorescenceFriday to an image I took years ago of an embryonic kidney from a TCF/Lef:H2B-GFP transgenic mouse highlighting active Wnt signaling

🚨 The ERA - European Renal Association Immunonephrology Working Group is proud to share our latest publication, focusing on the management of adult patients with podocytopathies (MCD and FSGS). We propose that rituximab should be upgraded in the next KDIGO update ... academic.oup.com/ndt/advance-ar…

TODAY at ERA - European Renal Association in Stockholm: Florian Florian Siegerist, my talented former postdoc, will give an exciting talk on “Super-resolution Microscopy: A technique to revolutionize research and diagnosis of glomerulopathy”. This talk promises to be a benchmark for both researchers,

Great achievement by the team around Tobias B. Huber and Nicola M. Tomas on the further description of anti nephrin antibodies in minimal change disease initially described by Astrid Weins et al. Huge congratulations to everybody on the team!

Revolutionary super resolution microscopy 🔬in GN research ✨by Florian Siegerist Prof Dr. rer. nat. Nicole Endlich ERA - European Renal Association #ERA24