AML with inv(3)(q21.3q26.2);GATA2,MECOM: Increased numbers of megakaryocytes (as highlighted by CD61), with many small forms identified. Monosomy 7 (as detected by cytogenetics in this case) is the most frequent secondary karyotypic abnormality #Hemepath #HemepathMDA #leusm

(1/5) Key points from today's amazing lecture by LJMedeirosMD : Major mutations in pathways involved in DLBCL+ potential targets that can be assessed by IHC, summarized in the pics below #hemepath #hemepathmda #virtualpath #virtualhemepathmda Kirill Lyapichev MD Anderson Cancer Center

(5/5) Features of plasmablastic lymphoma and differential diagnosis of lymphomas with plasmacytic features #hemepath #hemepathmda #virtualpath #virtualhemepathmda

Vascular transformation of sinuses of lymph node (nodal angiomatosis) is just an incidental finding in nodes to make us nervous....

Our study on 'ANKRD26-related Thrombocytopenia 2 with a Baseline Increase in Blasts: Implications for Clinical Surveillance' is now published in @BloodJournal First Edition ashpublications.org/blood/article-… #hemepath #leusm #pathx

Micronodular T-cell/histiocyte-rich large B-cell lymphoma (MTLBL) is unique variant of T-cell/histiocyte-rich large B-cell lymphoma, characterized by primary splenic presentation #Hemepath #PathX #PathTwitter #Lymsm #Surgpath #MedEd #GIpath #SpleenPath

Burkitt lymphoma in action, completely involving one lymph node and crossing into an adjacent lymph node with a normal architecture #Hemepath #Lymsm #PathX #PathTwitter #Surgpath #MedEd

New academic year & I’d love for every PGY1 #pathology resident to recognize acute monocytic leukemia 🔬 🌟 sky :common in monocytic AML (⬆️ cell turnover) if U’re like me, old-fashioned &still into #FAB: this is M5b (with maturing monocytes) #hemepath

3 yo boy. Past medical history of B-ALL, KMT2A-R at age of one. S/P ASCT. Now presents with a paraspinal mass. Negative stains: CD19, CD79a, CD20, PAX5, TdT, CD3, CD34, CD117, MPO. FISH on fresh tissue shows 100% KMT2A-R. What do you think is happening here? Answer in comments 😉

Vascular transformation of sinuses, also called nodal angiomatosis: Usually found incidentally after resection of a nearby tumor, due to obstruction of lymphatic efferent vessels or venous obstruction #Hemepath #PathX #Surgpath #PathTwitter #MedEd

Perifollicular ring-like granuloma is a nonspecific morphologic feature that should prompt consideration of IgG4-related disease, particularly in lymph nodes with plasmacytosis #Hemepath #Surgpath #PathX #PathTwitter #MedEd #SoMe

#Hemepath #Surgpath #Pathology Multiple neck lymph nodes. It is obviously a Lymphoma. I requested immunostains to classify. Your preliminary diagnosis ?

In light of #TatianaSchlossberg sharing her 💔 battle w/AML w/ inv(3) (MECOM rearranged) I’m reviving 👇🏼 🧵 to shed more💡on this disease in hopes of ⬆️ funding for AML. I dream of a day when AML w/ inv(3) is no longer a death sentence 🙏🏻 ASH ASCO #leusm #hemepath

A case of extranodal NK/T cell lymphoma in the uterus. - Angiocentric and angiodestructive pattern - NK cell lineage more common than T cell lineage - Positive for EBER-ISH Whole slide: pathlibrary.com/slidebox/?case…

Let’s review inflammatory lesions of the breast this week! 🤒 Case of Breast Implant Associated Anaplastic Large T-Cell Lymphoma (BIA-ALCL) 🔬 The lymphoma can present either as a mass or effusion associated with a textured implant. #PathX #PathTwitter #breastpath

The Pautrier microabscesses don't get much better. Pautrier microabscesses are intraepidermal nests of atypical lymphocytes commonly associated with mycosis fungoides, a type of cutaneous T-cell lymphoma.

Peripheral blood smear of a 30 yr old with fever, weight loss, and fatigue 😭 These cells are enough to make a diagnosis! 📸 ASH image bank

Another of #hemepath 🩸 🔬marathon in the books, on the new #Leukemia service. Here’s a select handful of interesting cases I saw today… 🧵 1. Acute erythroid leukemia, TP53 mutated. Note the elongated “carrot – like” nucleoli, often membrane-bound (arrow) on H&E, the large

A 67 yr old ♀️ presents with fatigue and epistaxis 🩸 Pancytopenia on blood work Myeloid blasts on blood smear 👇🏽 What's the most likely cytogenetic abnormality?

Classic IHC for mycosis fungoides. CD4+/CD3+ T-cells clustered into intraepidermal Pautrier microabscesses. See those scattered CD4+/CD3- cells in epidermis? Those are normal Langerhans cells. Don’t use CD4 alone for MF. #dermpath #Pathology #dermatology #hemepath