Newly Discovered PNS Microglia Found to Regulate Neuron Size, by @hanjie_li and his lab. 👍

Interdisciplinary immunologists at all levels WANTED! Faculty recruitment at Institute for Immunology, Tsinghua University, Beijing. PLEASE SPREAD THE WORD!

Congratulations to physicist Carl Bender of WashU Arts & Sciences and immunologist Marco Colonna WashU Medicine, who have been elected to the American Academy of Arts & Sciences for their pioneering work in quantum theory and immune pathways in Alzheimer’s. bit.ly/42SK87N

Congratulations, Marco The Colonna Lab! Well deserved!

The brain & immune system are more connected than ever imagined. In this issue of Immunity, 9 articles explore major advances & future directions in neuroimmunology. Take a look! hubs.li/Q03lzQ3H0

Big shoutout to Brown’s group: IRF8-dependent TC are essential for inducing food-specific pTregs & establishing oral tolerance! In line with recent work from Mucida’s, Littman’s, Gardner’s, and our group highlighting the role of RORγt⁺ APC in this process.rb.gy/rej77q

As RORγt⁺ APC gain attention for their tolerogenic roles, Schraml’s group also highlights their inflammatory potential. Key questions remain: How are RORγt⁺ APC specified? Are eTAC and RORγt⁺ DC distinct or the same? What dictates tolerance vs. inflammation? Fast-moving field!

Find the referenced papers below: Brown: rb.gy/rej77q Mucida: rb.gy/1ulzqt Littman: rb.gy/9v8ke8 Gardner: shorturl.at/vTk7k Schraml: rb.gy/yhw499 Colonna: rb.gy/w50y70

🔬 OBS Seminar Feeding Tolerance: The Role of RORγt⁺ Tolerogenic DCs in Shaping Gut Immunity 🗣️ Lihui Fu New York University 🗣️ Patrick Fernandes-Rodrigues The Colonna Lab @wusm_pathology Test Account 🧑‍🏫 Javier Orozco 🗓️ Thu, June 12th, 11 pm ET 👇 us02web.zoom.us/meeting/regist…

Zhangying Cai, Shoutang Wang, Marco Colonna et al. show that Loss of ATG7 in #microglia impairs UPR, triggers #ferroptosis, and weakens amyloid pathology control. hubs.la/Q03pZLRg0 📘 In #Neuroimmunology & #Neurodegeneration 2025: hubs.la/Q03pZMWk0

OBS SPEAKER HIGHLIGHT Feeding Tolerance: The Role of RORγt⁺ Tolerogenic DCs in Shaping Gut Immunity 🗣️ Patrick Fernandes-Rodrigues The Colonna Lab Test Account 📆 Thu, June 12, 11 pm ET 👉 Registration: us02web.zoom.us/meeting/regist…

Mutations in the human CSF1R gene impact microglia’s maintenance of brain white matter integrity Nature Immunology The Colonna Lab Siling Du nature.com/articles/s4159… nature.com/articles/s4159…

Mutations in the human CSF1R gene impact microglia’s maintenance of brain white matter integrity nature.com/articles/s4159…

Our new study by Siling Du reveals how CSF1R mutations in adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) disrupt glial homeostasis. Key roles for oligodendrocytes, astrocytes & STAT3 signaling. nature.com/articles/s4159…

🧵1/ Excited to share my first publication from the ColonnaLab in Nature Immunology! We investigated how mutations in the human CSF1R gene disrupt microglia and impair white matter integrity in a rare but devastating neurodegeneration called ALSP. nature.com/articles/s4159…

Check out Research Briefing for our recent paper in Nature Immunology Siling Du nature.com/articles/s4159…

🗣️ Patrick Fernandes-Rodrigues talk is now on Youtube! The Colonna Lab Test Account 👉 Rorγt-positive dendritic cells are required for the induction of peripheral regulatory T cells in response to oral antigens youtube.com/watch?v=KNnJRU…

Scientists discover that the protein AGPAT4 is heavily involved in #HCC tumor metabolism, plasticity, and resistance to #sorafenib, and discover an AGPAT4 inhibitor that can sensitize tumors to treatment in mice. Stephanie Ma HKU Medicine scim.ag/4l6etXy

Our new study led by Bishan Bhattarai shows that circadian proteins REV-ERBα/β protect gut health by maintaining ILC3 homeostasis. Without them, ILC3s turn into IFNγ+ ILC1s, fueling inflammation. Chick it out! nature.com/articles/s4159…

Meet MapMyCells! This tool saves neuroscientists precious time by comparing their data to massive, high-quality reference datasets, incl. our whole mouse brain multi-omics atlas and Seattle Alzheimer’s Disease Brain Cell Atlas. 🔗 portal.brain-map.org/atlases-and-da… #OpenScienceWeek