Developing a safe and effective vaccine (for any disease) is a great achievement, but it could all come to naught if we can’t address the ever-growing issue of vaccine hesitancy.

This is HUGE news! MV140, a sublingual vaccine developed to prevent UTIs, showed REMARKABLE success and safely reduced the risk of recurrent UTIs by UP TO 80%. The vaccine not only reduced risk but also enabled a significant number of participants to be completely UTI-free!🧵⬇️

Have you ever wondered why some people get more sick from the flu than others? Check out our latest paper from @rmettelman and Aisha Souquette exploring diverse immune correlates of protection against flu nature.com/articles/s4159… A brief 🧵

A new study offers clues as to how exhaustion could arise in people with myalgic encephalomyelitis/chronic fatigue syndrome (#MECFS)—and potentially related conditions such as #LongCovid. scim.ag/3NZ

Fantastic projections by Dr. Oliver Brady of dengue incidence until the end of the century in Southeast Asia. nature.com/articles/s4146…

Immune monitoring-guided vs fixed duration of antiviral prophylaxis against cytomegalovirus in solid-organ transplant recipients. A Multicenter, Randomized Clinical Trial ✅ Just Accepted 🔓 Open Access bit.ly/3PTHWYB

Wow! 🔥 Just published 🔥 Science Translational Medicine A remarkable work by Brad Spellberg et Al A Protein-Free Vaccine Stimulates Innate Immunity and protects against bacterial & fungal pathogens that cause HAIs If it works in humans the way it does in mice? Game changer! science.org/doi/full/10.11…

Now 261 confirmed cases of #Dengue in Italy of which 49 are locally acquired. New data on where introductions were from included now on the official dashboard: epicentro.iss.it/arbovirosi/das…

The ACORN study of cefepime vs pip-tazo serves as a great lesson in how to do randomized trials in hospitalized patients. Now that we have this model, let's do more of this, please! Here's why it's so important: blogs.jwatch.org/hiv-id-observa…

For the first time, scientists have deliberately infected people with Zika virus to learn whether the strategy could help to test vaccines in the future. I wrote about the results - presented today at the ASTMH meeting - for nature #TropMed23 nature.com/articles/d4158…

Global and cell type-specific immunological hallmarks of severe dengue progression identified via a systems immunology approach | Nature Immunology nature.com/articles/s4159…

In this perspective piece in ⁦PLOS Biology⁩, ⁦we discuss the importance of integrating T cell immunity as a measure of vaccine efficacy, when developing future vaccines for pandemic preparedness. ⁦Eng Eong Ooi⁩ journals.plos.org/plosbiology/ar…

New comment: Achieving zero deaths from dengue virus under evolving population immunity thelancet.com/journals/lanin…

We are hiring!!! Interested in exploring the role of T cells in the control of viral infections and cancer? Join our team Duke-NUS Medical School in Singapore 🇸🇬! Apply here: 👉Postdoc: careers.nus.edu.sg/DukeNUS/job/DU… 👉Research Assistant (Local / PR only): careers.nus.edu.sg/DukeNUS/job/DU…

Despite herculean efforts in vector control, dengue cases continue to surge. Vaccination would boost population immunity…unfortunately we still await licensing of Qdenga in Singapore (although already approved by EMA and several neighbouring countries). straitstimes.com/singapore/over…

Low-dose dengue virus 3 human challenge model: a phase 1 open-label study | Nature Microbiology nature.com/articles/s4156…

IN FOCUS: Is Southeast Asia losing the battle against dengue? With global warming, the no. of dengue infections are expected to ⬆️. Multiple strategies implemented in concert will be needed to address this increasing trend. channelnewsasia.com/asia/dengue-fe…

Immunity is now so high, it raises questions about the usefulness of COVID-19 challenge trials for testing vaccines, drugs and other therapeutics. “If you can’t get people infected, then you can’t test those things,"

2024 is the worst year for dengue cases on record, with over 10 million cases already reported globally. Our latest Editorial highlights the need for a multipronged and multidisciplinary approach to halt the spread of dengue virus: hubs.li/Q02HNd1z0

Dengue virus infection among renal transplant recipients in Singapore: a 15-yr single centre retrospective review journals.lww.com/smj/fulltext/2…