Thoughts on AI (warning: long thread). I’ve been formulating these ideas for a long time…. not months, decades. But only recently has the acceleration made the immediacy of them relevant to almost everyone. They are also very incomplete. But here goes.

Anthropic just dropped Free AI courses on: - Prompt Engineering - Building agents - Best practices for Agentic Coding - Collaborate with AI systems .... and so much more! 9 best guides you don’t want to miss:

🧵1/ We Tahoe Therapeutics (Formerly Vevo) just published a new post on the Tahoe blog—a story of how we used Tahoe-100M, the world’s largest drug-perturbed single-cell dataset, to find compounds that upregulate MHC-I and make tumors more visible to the immune system. Here’s how 🧬🔍👇

Any time I feel like I'm not making progress, I'm simply trying to do too many things. I've learned you can only accelerate one area of your life or business at a time. Everything else has to go on "maintenance mode." Easy to say, much harder to put into practice.

Congrats to Simon Willison (Simon Willison) on 23 years (!!) of blogging. Really excellent LLM blog, I sub & read everything: simonwillison.net (e.g. I sub via RSS/Atom on NetNewsWire) +If you consistently enjoy the content like I do, sponsor on GitHub: github.com/sponsors/simonw

Claude is now being listed as an author on arXiv papers A response paper to Apple's "Illusion of Thinking" work just dropped with Claude Opus as first author, critiquing their experimental design and arguing the reasoning collapse was actually just token limit constraints.

Nice - my AI startup school talk is now up! Chapters: 0:00 Imo fair to say that software is changing quite fundamentally again. LLMs are a new kind of computer, and you program them *in English*. Hence I think they are well deserving of a major version upgrade in terms of

The single most undervalued fact of linear algebra: matrices are graphs, and graphs are matrices. Encoding matrices as graphs is a cheat code, making complex behavior simple to study. Let me show you how!

🚫🕶️ I've been building an XR app for a real-world ad blocker using Snap Spectacles. It uses Gemini to detect and block ads in the environment. It’s still early and experimental, but it’s exciting to imagine a future where you control the physical content you see.

Just published Science Magazine Engineering T cells within the body, a big step forward for treating cancer and autoimmune diseases, as demonstrated in animal models science.org/doi/10.1126/sc… science.org/doi/10.1126/sc…

This study is being massively misinterpreted. College students who wrote an essay with LLM help engaged less with the essay & thus were less engaged when (a total of 9 people) were asked to do similar work weeks later. LLMs do not rot your brain. Being lazy & not learning does.

“Do what you say you’re going to do” is underrated advice.

Delighted to announce Arc Institute's Virtual Cell Challenge - a recurring, open, community-driven challenge to benchmark cellular foundation models See our announcement in Cell below, with prizes up to $100,000, sponsored by @Nvidia 10x Genomics Ultima Genomics!

CRISPR pioneer George Church says AI is letting us steer evolution, and biology is becoming a kind of computer. “Evolution might incorporate a few base pair changes in a million years. Now we can make billions of changes in an afternoon.” AI designs the possibilities. Biology

How to build a thriving open source community by writing code like bacteria do 🦠. Bacterial code (genomes) are: - small (each line of code costs energy) - modular (organized into groups of swappable operons) - self-contained (easily "copy paste-able" via horizontal gene

🚀 Excited to share our latest protocol in Nature Protocols : "scGPT: End-to-end Protocol for Fine-tuned Retinal Cell Type Annotation"! Single-cell RNA-seq is transforming biology, but annotating large-scale, high-resolution data is challenging. Our team introduces a powerful

'water is transparent only within a very narrow band of the electromagnetic spectrum, so living organisms evolved sensitivity to that band, and that's what we now call "visible light". ' (found via HN)

The invention of modern writing instruments like the typewriter made writing easier, but they also led to the rise of writer’s block, where deciding what to write became the bottleneck. Similarly, the invention of agentic coding assistants has led to a new builder’s block, where

this is what's keeping me up at night these days.... 1. ai girlfriends/boyfriends will become a $50B market and nobody will talk about it publicly. but check the app store rankings at 2am. Virtual friends/girlfriends era is just beginning 😅 2. the most valuable skill in 2026

you don’t need to overthink it. AI allows you to take a boring product and make it magical again and BILLIONS of dollars are up for grabs think about it: every category people wrote off as “done” is wide open. notes, calendars, email, fitness, budgeting, shopping lists. the