The accurate measurement of telomere length is challenging due to its repetitive nature. At #nanoporeconf, Tobias Schmidt will discuss how nanopore technology can overcome this challenge by resolving these long & repetitive regions. Read here: bit.ly/3rMY05e

Visualization water turning into ice

Happy #WorldScienceDay! To celebrate we're offering 5 free in-person tickets to NCM Houston (6th Dec). To be with in a chance of winning: like, retweet and comment why you would like to join us in Houston by 11:59 (PT) Tuesday #nanoporeconf 1/3

Only 2 weeks to go until #nanoporeconf NCM 2023 Houston! Join us on 5th - 6th December for one of the biggest #nanoporeconf of the year! View the agenda & activates, & grab your ticket here: bit.ly/3tkNse5

Our preprint “High resolution long-read telomere sequencing reveals dynamic mechanisms in aging and cancer” is now on bioRxiv. biorxiv.org/content/10.110…

Thrilled to see Telo-seq out (also in review). Telo-seq has come a long way since our first discussions with the The Karlseder Lab and has been released as a workflow community.nanoporetech.com/posts/telo-seq…. Count telomere and sub-telomere length at base resolution - methylation profile included!

Also, be sure to catch Tobias from the The Karlseder Lab's presentation on Telo-seq at the nanopore community meeting in Houston next week nanoporetech.com/about/events/c…

Learn how The Karlseder Lab & team used nanopore technology to investigate telomere shortening during cellular aging. Check out how they also studied how alternative lengthening of telomeres and telomerase impact iPSCs and cancer cells. Read more: bit.ly/46AgRPb

Learn more about this research at NCM Houston. #nanoporeconf. x.com/nanopore/statu…

periodic reminder of mRNA vs. protein levels in CD4+ T cells Ming "Tommy" Tang

“Transposable elements contribute to nearly 80% of human-specific candidate cis-regulatory elements in cortical cells” 🧠 …🤯 literally! Amazing dataset 🔥 Congrats to all involved! nature.com/articles/s4158…

See our new preprint pairing Oxford Nanopore single-cell sequencing with 10x Genomics for full-length antibody repertoire sequencing of single B cells, in collaboration with Prof. Dr. Benhur Lee, MD 🦠🧬🔬 at Icahn School of Medicine at Mount Sinai. A thread 🧵 (1/14) biorxiv.org/content/10.110…

New paper demonstrates resolving the full-length antibody repertoire of individual B cells. This research could improve our understanding of the immune system, auto-immune diseases and help to develop better therapeutics. Read more 👇

We started this work in NYC in the spring of 2020, looking at COVID-19 antibodies, so seeing it on paper feels cathartic. We used Oxford Nanopore native gDNA and full-length RNA seq to uncover insights into complex immune system genetics, paving the way toward antibody therapies.

Towards accesible brain-tumor classification at the point of care Nanopore methylation sequencing from Formalin Fixed Paraffin Embedded (FFPE) pathology samples medrxiv.org/cgi/content/sh… #medRxiv

We are excited that our study on telomere sequencing in collaboration with Oxford Nanopore is published nature.com/articles/s4146… We developed Telo-seq, a method to determine the length and composition of entire human telomeres in bulk, chromosome arm and in some cases allelic resolution

This collaboration was highly successful, enabling us to answer intriguing biological questions through advancements in the Oxford Nanopore platform, which now allows for precise base- and modification calling even in the repetitive telomeric regions

Applications group presenting breadth of data available from a single Oxford Nanopore flowcell. #nanoporeconf

Wanqing Shao is evaluating phasing methods to understand genetic variants in clinically relevant genes. Using nanopore sequencing, she reduced phasing errors & highlighted the impact of read quality, depth, & alignment on accuracy as well as enhanced disease variant detection.

At #nanoporeconf, Stephanie Chrysanthou explored #nanopore sequencing to detect germline mutations, faster & more flexibly. Promising results show concordance with MSK-IMPACT and the potential for a customisable, rapid, and cost-effective workflow, in the future.