I brought the two Gitlers together. My contribution to #grc molecular and cellular neurobiology #ventura

Take a peek at our newly released manuscript at Brain! academic.oup.com/brain/advance-… We block the suggested pathogenic B6/B7 loop in misfolded SOD1 with scFv intrabody using AAV as a delivery vector in mice model of ALS. This treatment substantially extends mice's life expectancy.

OK then, our paper eLife - the journal. Conceived by Daniel Gitler & transcontinental collab. Lead authors Alexandra (Sasha) Stavsky & Leonardo Parra-Rivas. Thanks to anon reviewers ("highly relevant" "elegant"). Previously, we showed synapsin binds alpha-synuclein and is necessary for a-syn function.🧵1/10

Our paper providing evidence for age-related changes in the CD4 T-cell subset organization in ALS is online in the Journal of Neuroinflammation. Many thanks to the Monsonego's group for the wonderful collaboration. rdcu.be/dvNst

#PeerReview from eLife - the journal of 👉🏿 Synapsin E-domain is essential for α-synuclein function biorxiv.org/content/10.110… #biorxiv_neursci #reviewedpreprint

...perhaps inconsequential to the world, but one of those rare "I can't believe it" #science moments that makes one giddy.

Very happy our cautionary tale of GECI expression in the hippocampus is out in eLife - the journal. elifesciences.org/articles/93804 We describe Ca2+ waves though the hippocampus. Mesmerising but artefact of GECI expression. Also a tweet print x.com/tonykellyEU/st…. 1/3