We developed a novel reaction that enables a direct synthesis of amines from olefins via C=C bond cleavage. This process which we termed Triazenolysis represents an aza-version of ozonolysis reaction. Congrats to all involved Nature Chemistry Technion Israel nature.com/articles/s4155…

'How do I thianthrenate X?' – In our new article in J. Am. Chem. Soc., Dilgam Ahmadli presents simple guidelines for selecting reaction conditions and with our collaborators from @syngenta developed a robust diversification platform for further functionalizations! pubs.acs.org/doi/10.1021/ja…

Happy to share our review on "Recent Developments for the Ring Opening of Pyrrolidines and Unstrained Cyclic Amines via C–N Bond Cleavage" in EurJOC Chemistry Europe !! Congrats to Eisuke !! doi.org/10.1002/ejoc.2…

Synthesis of naphthalene derivatives via nitrogen-to-carbon transmutation of isoquinolines | Science Advances science.org/doi/10.1126/sc…

Congrats to Logan Bartholomew, Sojung Kim, Yusuke and collaborators Macroarc, Gilead Sciences, Merck on our indazole to benzimidazole conversion  onlinelibrary.wiley.com/doi/10.1002/an… coordinated with Leonori Lab  onlinelibrary.wiley.com/doi/10.1002/an…

Ready to take off as a synthetic chemist? Check out this tutorial review we wrote with Frank Glorius and Jasper Tyler! Glorius Group Frank Glorius

Visible Light-Promoted Deracemization of α-Amino Aldehyde by Synergistic Chiral Primary Amine and Hypervalent Iodine Catalysis | Journal of the American Chemical Society Tsinghua University Drug Discovery and Synthesis Highlights pubs.acs.org/doi/10.1021/ja…

EnantioCH by our MPAA ligand fills a gap in chiral technology; creating new chemical space for both drug discovery and chiral ligands: pubs.acs.org/articlesonrequ…

We've been drawn to selective activation of C(alkenyl)–H bonds for a long time. In a new ACS Catalysis paper, Juntao Sun & team turned attention to an interesting situation where functionalizing enamine-type azaheterocycles creates a chiral C–N axis. tinyurl.com/mpjjb99w

SAXITOXIN simplified: Appearing today in ChemRxiv is a short, highly scalable, convergent approach to this entire natural product family using a tactical combination of radical retrosynthesis, biocatalysis (in collaboration with Merck), and C–H functionalization logic:

Synthesis of Borane-Ammonia and its Application in the Titanium Tetrachloride Catalyzed Reduction of Carboxylic Acids, Including N-Protected Amino Acids Henry J. Hamann, Abdulkhaliq A. Alawaed, and P. Veeraraghavan Ramachandran orgsyn.org/demo.aspx?prep…

Check out our recent publication in J Org Chem/Org Lett on the anti-Markovnikov oxidation of alkenes enabled by photoexcited nitroarenes under iron Lewis-acid catalysis. pubs.acs.org/doi/10.1021/ac…. #photochemistry #nyuchemistry #nitroarenes

I really happy to share our lastest publication in J. Am. Chem. Soc. "Generation of Stereocenters via Single-Carbon-Atom Doping Using N-Isocyanides" Huge congrats to everyone involved! And excited to see my first paper as a corresponding author! pubs.acs.org/doi/10.1021/ja…

TEN STEPS TO A MARINE TREASURE: Gram-Scale Synthesis of Bipinnatin J – featuring methods that weren't known ≅3 years ago to forge 3 key C–C bonds... Appearing today in ChemRxiv (chemrxiv.org/engage/chemrxi…). Quick Summary: A concise, scalable total synthesis of (–)-Bipinnatin J

We’re excited to share our work that introduces singly N-protected O-vinylhydroxylamines as ring-annulation reagents for the synthesis of azaindolines and azaindoles. Congrats to Zach & Charlotte (Charlotte) and the Enamine (Enamine Ltd 🇺🇦) team! 🔗 chemrxiv.org/engage/chemrxi…

pKa Scale in DMSO

Please check out our latest achievement in C–C activation: Downsizing lactams via Rh-catalyzed C–C activation. sciencedirect.com/science/articl… Congratulations to Rui Rui Zhang and Kangmin Kangmin Wen

🚨 A single-atom swap could change the game in drug discovery! 🧪💥 We have just unveiled a CO-to-S atom swap method that turns ketones into sulfur-containing frameworks in complex, bioactive molecules in just two steps. science.org/doi/10.1126/sc… Congratulations to Zining.

Congrats to Ann-Sophie K. Paschke, Yannick, Bence B. Botlik, Erich Staudinger, Ori Green! "Carbon-to-nitrogen atom swap enables direct access to benzimidazoles from drug-like indoles" nature.com/articles/s4155…. Nature Chemistry

Atom-swapping in a saturated heterocycle? We report a photocatalytic transmutation strategy in nature that exchanges O within an oxetane for N, S, C & even dual atoms, simplifying access to a variety of non-aromatic cyclic pharmacophores & enabling late-stage editing of complex