“My name is Mike, this is Emily, and in the role of Chester Bennington this afternoon is each of you. Are you ready to sing with us?”🥹❤️ #LinkinPark

Is left atrial appendage occlusion a valuable treatment option for patients with atrial fibrillation and #breakthroughstroke despite anticoagulation therapy? @davidseiffge @boersma_lucas ja.ma/47BEHMx

Dual Antiplatelet Versus Alteplase for Early Neurologic Deterioration in Minor Stroke With Versus Without Large Vessel Occlusion: Prespecified Post Hoc Analysis of the ARAMIS Trial | Stroke ahajournals.org/doi/10.1161/ST…

Optimal timing of anticoagulation after acute ischaemic stroke with atrial fibrillation (OPTIMAS): a multicentre, blinded-endpoint, phase 4, randomised controlled trial - The Lancet thelancet.com/journals/lance…

Great collaboration between 🇩🇪 and 🇮🇹

Really interesting systematic review on the role of emerging blood biomarkers in the field of epilepsy ‼️Thanks to Annie, Prof Otto and the Halle team for involving me in this very nice work Samir Abu Rumeileh Lorenzo Barba sciencedirect.com/science/articl…

Check out our new study! ☑️p-tau 181 and 217 in blood are not as specific for AD as previously thought, ☑️they are also elevated in the blood of patients with ALS, ☑️IHC and MS analyses disclosed both p-tau species in muscle biopsies from ALS cases. nature.com/articles/s4146…

Auch bei Menschen mit Amyotropher Lateralsklerose (#ALS) sind die p-Tau-Proteine im Blut offenbar erhöht. Ist ein effektives #Alzheimer-Screening mittels p-Tau so überhaupt möglich? #pTau aerztezeitung.de/Medizin/p-Tau-…

P-tau isoforms used as AD biomarkers could also come from damaged muscles in ALS. ow.ly/eJB150Vl96i

Among cognitively healthy people who carried a familial #alzheimersdisease mutation, eight years of gantenerumab halved the odds of developing symptoms. @wustl ow.ly/q05T50VqVEP

In patients with posterior circulation stroke for whom thrombectomy was not planned, alteplase administered 4.5 to 24 hours after stroke onset resulted in less disability at 90 days than standard treatment. Full EXPECTS trial results: nej.md/3QTnMxG

Transplanting dopamine-releasing neurons into the brain is a promising regenerative therapy for Parkinson’s disease shown safe in two clinical trials nature nature.com/articles/d4158… nature.com/articles/s4158… nature.com/articles/s4158…

Immunoassay choice for #pTau217 is important! In this study, we show that LMW #pTau217 is more specific to Alzheimers pathology than HMW #pTau217 immunoassay designs – which can give false-positives. alz-journals.onlinelibrary.wiley.com/doi/10.1002/al… BioFINDER Oskar Hansson

Excited to see our latest work on serum synaptim markers out in Journal of Neurology, Neurosurgery and Psychiatry ! Nice collaboration of German, Italian and Spanish groups 🧠 Samir Abu Rumeileh jnnp.bmj.com/content/early/…

🧠💥 Oral anticoagulation after intracranial hemorrhage: risk or relief? 💊🩸 Patients with atrial fibrillation (AF) face a tough clinical dilemma when they have a history of intracranial hemorrhage (ICH): should we restart anticoagulation?

🔍 We conducted a systematic review and meta-analysis of randomized controlled trials (including the recently published PRESTIGE-AF) to shed light on this challenging scenario. Across 4 RCTs including 653 patients, our findings highlight a complex risk-benefit trade-off:

Reduced risk of ischemic stroke (RR 0.23) 🔴 Increased risk of recurrent ICH (RR 3.60) ⚖️ No clear net clinical benefit (RR 0.72) 💔 Fewer MACE, but 💉 more major bleeding events

These results highlight the need for individualized clinical decisions, better risk stratification tools, and (most importantly) rigorously designed future trials to guide anticoagulation strategies in this high-risk population.

👇 Read the full study in Journal of Neurology, Neurosurgery & Psychiatry: 🔗 jnnp.bmj.com/content/early/… Many thanks to Professor Kevin Sheth for the beautiful editorial!! 🙏 👉 jnnp.bmj.com/content/early/…

☑️CSF levels of beta-syn, neurogranin, and NfL are increased in both infectious and autoimmune neurologic disease and are associated with clinical severity and short-term outcome. ☑️Read our new paper in Neurology, Neuroimmunology & Neuroinflammation neurology.org/doi/pdfdirect/…