El próximo Viernes, 20 de junio a las 12:30 hrs. en la Sala Washington Buño del #InstitutoCajal, seminario presencial del Dr. Javier Oroz (Blas Cabrera Institute for Physical Chemistry), con el título: "Mechanistic basis for protein loss of function in rare human diseases".

Dysfunctional mitochondria trap proteins in the intermembrane space | The EMBO Journal embopress.org/doi/full/10.10…

Job offer! We are looking for a motivated postdoctoral researcher with expertise in cancer metabolism/immunology to investigate metabolic heterogeneity as a driver of cancer metastasis. Centro de Biología Molecular Severo Ochoa CRIS contra el cáncer #cancermetabolism #immunometabolism

#REVIEW 🚨 Amit et al. outline the reciprocal interactions among neurons, immune cells and tumour cells that regulate peripheral antitumour immune responses and discuss how these mechanisms could be leveraged to enhance immunotherapy. 📖 ⬇️ bit.ly/4kLWyGq

Mitochondrial fumarate inhibits Parkin-mediated mitophagy dlvr.it/TLWFgR

🚫 No dyes. No bleaching. 🔬 Just AI + label-free microscopy = vivid virtually stained images New in Nature Machine Intelligence: A deep learning model that enables robust virtual staining across microscopes, cell types & conditions. #CZBiohubSF Shalin Mehta explains:

🚨 New review out in Nature Reviews Molecular Cell Biology! Expert recommendations for studying organelle contact sites and introduce the concept of organelle contactome 🧬nature.com/articles/s4158… Huge thanks to editor Lisa Heinke for the support and guidance! 🙏Nature Reviews Molecular Cell Biology

Investigadores de Países Bajos han usado unos editores de bases mitocondriales (basados en #TALE) para corregir mutaciones en fibroblastos de pacientes afectados por enfermedades genéticas mitocondriales. Han publicado su trabajo pionero en PLOS Biology journals.plos.org/plosbiology/ar…

CellMarker 2.0 An updated database of manually curated cell markers in human/mouse and web tools based on scRNA-seq data http://117.50.127.228/CellMarker/index.html A nice resource for cell type markers for supervised clustering😁 Nucleic Acids Res 2023 academic.oup.com/nar/article/51…

New study from the lab where we find innate immune activation to play a critical role in forming TNTs and a-Syn aggregate spread from neuronal cells to microglia

Nerve-to-cancer transfer of mitochondria during cancer metastasis nature.com/articles/s4158…

Neuronal glycogen breakdown mitigates tauopathy via pentose-phosphate-pathway-mediated oxidative stress reduction go.nature.com/4ldPWRA

New kind of efferocytosis? Cell entrapment! nature.com/articles/s4141… Normally, macrophages engulf dying, apoptotic cells, e.g. neutrophils - process known as efferocytosis. But if neutrophils were infected with Porphyromonas gingivalis, most common bad oral bacteria, they are

Opportunities and challenges of single-cell and spatially resolved genomics methods for neuroscience discovery nature.com/articles/s4159…

Spatiotemporal transcriptomic maps of mouse intracerebral hemorrhage at single-cell resolution: Neuron cell.com/neuron/fulltex…

Super-resolution microscopy of mitochondrial mRNAs | Nature Communications nature.com/articles/s4146…

Pancreatic cancer cells can hijack neurons to facility their growth and spread. Here's the single-cell map (spatial omics) of the process cell.com/cancer-cell/fu…

mtKO: A dedicated guide RNA library for mitochondria research | PNAS pnas.org/doi/10.1073/pn…

#Throwback COMMENT | Gary Siuzdak Subcellular quantitative imaging of metabolites at the organelle level nature.com/articles/s4225…

Absolutely delighted to be part of this editorial, beautifully led by Juan Pedro Bolaños, defending the role of glial cells in brain energy metabolism 🤩🤩 onlinelibrary.wiley.com/doi/10.1111/jn…