5. REVERSE-IT Trial : Bentracimab (PB2452), a recombinant IgG1 monoclonal antibody that reverses the effect of ticagrelor, is safe and effective in promptly reversing the antiplatelet effect of ticagrelor among patients undergoing urgent surgery/procedure or with major bleeding.

Using the Vascular Events in Surgery Patients Cohort Evaluation (VISION) Cardiac Surgery Biobank, Spence et al. identified 26 biomarkers associated with delirium after cardiac surgery. Learn more: ow.ly/rIjk50VuFim

🚨 ​​New Study Alert!​​ 🚨 Spinal vs. General Anesthesia in Vascular Surgery: What’s the Verdict? The study randomized trial of 128 patients 👉 Spinal anesthesia may benefit hemodynamic stability in high-risk patients, but PPC risk remains similar jcvaonline.com/article/S1053-…

Big news for #EBM! Just out in #BMJ, ROBUST-RCT, pristinely developed, innovative, simple, user-friendly instrument for risk of bias assessment in #RCTs far superior to anything before, will become standard outside of Cochrane and in #Cochrane if they let folks use it.

"Stopping β-blockers post-MI? The ABYSS Trial just dropped a bombshell! 💥​​ 📉 Interrupting β-blockers 6+ months after MI (EF ≥40%) led to ​​↑23.8% CV events​​ vs 21.1% (continuation group)! 🔗 Dive deeper: jcvaonline.com/article/S1053-… #ABYSS_Trial #MI #BetaBlockers

important context: Epic is a deeply evil company and probably the one company most directly responsible for the cost of health care in the US Judy Faulkner is a bad person who has consciously chosen strategies that harm hospitals and patients with monopolistic practices

Pre-operative use of GLP-1s is known to delay gastric emptying, but does that translate to an increased risk of pulmonary aspiration? This systematic review and meta-analysis suggests NO. #GLP-1 #anaesthesia #medicine doi.org/10.1111/anae.1…

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In critically ill patients, neither dexmedetomidine nor clonidine was superior to propofol in reducing time to successful extubation. #ATS2025 ja.ma/3SFgz54

🧵 Is Proximal Intercostal Block a safer alternative in arrhythmia care?? Key findings: ✅100% of successful blocks reached the cervicothoracic chain ❌PVB/epidural spread inconsistent 💡Suggests direct fascial spread as main mechanism 🔗 doi.org/10.1136/rapm-2…

eFAST exam shows high specificity, but low sensitivity in most pathologies in penetrating thoracic trauma. Urgent interventions were frequently required in patients with false negative studies. journals.lww.com/jtrauma/abstra…

Turns out targeting a particular blood pressure while under anaesthesia doesn’t make much difference, and the permissive group actually had less atrial fibrillation. #rcoaupdates

Presented at #CCR25: In the ANH phase 3 trial involving adult patients undergoing elective cardiac surgery, acute normovolemic hemodilution did not reduce the number of patients receiving allogeneic red-cell transfusion. Full trial results: nej.md/3FxdMrW

Presented at #CCR25: In a cluster-randomized, crossover trial, hospital-wide use of lactated Ringer’s solution as compared with normal saline did not alter the incidence of death or hospital readmission within 90 days. Full trial results: nej.md/45SaEBs

There is no clinically meaninful differences in postoperative chronic #opioid use or #dependence in groups who received a single-shot peripheral nerve block or continuous catheter infusion during total knee arthroplasties. #pain #TKR #regional bjanaesthesia.org.uk/article/S0007-…

In a large retrospective study of Florida patients undergoing major diagnostic or therapeutic surgery, Epstein et al. compared those who survived to discharge or died between the elective and nonelective groups. Learn more: ow.ly/iB2V50Wb357

Nine uncomfortable facts about Global longitudinal left ventricular strain.

PRINCE Randomized Trial: Remote ischemic preconditioning (RIPC) in noncardiac surgery did not reduce postoperative myocardial injury or improve clinical outcomes compared to sham treatment. ahajournals.org/doi/epdf/10.11…

🔍 The IMPROVE trial, a 12-week cognitive and physical training intervention for ICU delirium survivors, did not result in improved cognitive, physical, mental health, or quality of life measures. ✅ Read the research in CCM: ow.ly/q8b950WG1Qv #CritCareMed SCCM Sikandar Khan, DO, MS